Structural feature of TRAFs, their related human diseases and therapeutic intervention
DC Field | Value | Language |
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dc.contributor.author | Park, Hyun Ho | - |
dc.date.accessioned | 2021-11-22T06:40:26Z | - |
dc.date.available | 2021-11-22T06:40:26Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51718 | - |
dc.description.abstract | Several studies have been conducted over the years to unravel the structural information on the receptors that bind to tumor necrosis factor receptor-associated factor (TRAF) and the driving forces for the TRAF/receptor complex. In addition, studies have also been performed to highlight the influence of TRAF malfunctioning and mutations on the development of human disease. However, a holistic study that systematically summarizes the available information and the existing clinical trends towards development of the TRAF-targeting drugs has not been conducted to date. Herein, I reviewed existing research that focused on the structural information of various receptors recognized by the different members of the TRAF family. I also reviewed studies on the different human diseases that occur due to TRAF malfunctioning or mutations as well as the clinical trials undertaken to treat TRAF-associated diseases. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Structural feature of TRAFs, their related human diseases and therapeutic intervention | - |
dc.title.alternative | Structural feature of TRAFs, their related human diseases and therapeutic intervention | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12272-021-01330-w | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.44, no.5, pp 475 - 486 | - |
dc.identifier.kciid | ART002723441 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000648799400001 | - |
dc.identifier.scopusid | 2-s2.0-85105477396 | - |
dc.citation.endPage | 486 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 475 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 44 | - |
dc.type.docType | Review | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Innate immunity | - |
dc.subject.keywordAuthor | TRAF family | - |
dc.subject.keywordAuthor | TRAF domain | - |
dc.subject.keywordAuthor | TRAF-associated diseases | - |
dc.subject.keywordAuthor | Structure-based drug design | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | MOLECULAR-BASIS | - |
dc.subject.keywordPlus | SIGNALING MOLECULES | - |
dc.subject.keywordPlus | ALTERED EXPRESSION | - |
dc.subject.keywordPlus | GENETIC-VARIATION | - |
dc.subject.keywordPlus | ADAPTER PROTEINS | - |
dc.subject.keywordPlus | FAMILY GENES | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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