Effect of a novel piperazine compound on cancer cells
DC Field | Value | Language |
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dc.contributor.author | Jeon, So Hyun | - |
dc.contributor.author | Shin, Cha-Gyun | - |
dc.date.accessioned | 2021-11-26T01:40:20Z | - |
dc.date.available | 2021-11-26T01:40:20Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2468-0834 | - |
dc.identifier.issn | 2468-0842 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51863 | - |
dc.description.abstract | Many drugs have been developed for anticancer chemotherapy. However, more anti-cancer drugs should be developed from potential chemicals to circumvent the disadvantages of existing drugs. Most anti-cancer chemicals induce apoptosis in cancer cells. This study tested the efficiency of a new chemical, the piperazine derivative 1-[2-(Allylthio) benzoyl]-4-(4-methoxyphenyl) piperazine (CB01), on glioblastoma (U87) and cervix cancer (HeLa) cells. CB01 was highly cytotoxic to these cells (IC50S < 50 nM) and induced the traditional apoptotic symptoms of DNA fragmentation and nuclear condensation at 40 nM. Western-blot analysis of the cell lysates revealed that the intracellular apoptotic marker proteins, such as cleaved caspase-3, cytochrome c, and Bax, were highly upregulated in the CB01-treated cells. Furthermore, increased activities of caspase-3 and -9, but not caspase-8, were observed. Therefore, these results suggest that CB01 can act as an anticancer chemotherapeutic by stimulating the intrinsic mitochondrial signaling pathway to induce cytotoxicity and apoptosis in cancer cells. © 2021, The Author(s). | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Science and Business Media B.V. | - |
dc.title | Effect of a novel piperazine compound on cancer cells | - |
dc.title.alternative | Effect of a novel piperazine compound on cancer cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13765-021-00651-0 | - |
dc.identifier.bibliographicCitation | Applied Biological Chemistry, v.64, no.1, pp 1 - 7 | - |
dc.identifier.kciid | ART002798255 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000719880500001 | - |
dc.identifier.scopusid | 2-s2.0-85119131478 | - |
dc.citation.endPage | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Applied Biological Chemistry | - |
dc.citation.volume | 64 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Human cancer cells | - |
dc.subject.keywordAuthor | Piperazine derivative | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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