TCR Transgenic Mice: A Valuable Tool for Studying Viral Immunopathogenesis Mechanisms
DC Field | Value | Language |
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dc.contributor.author | Cho, Yong-Bin | - |
dc.contributor.author | Lee, In-Gu | - |
dc.contributor.author | Joo, Yong-Hyun | - |
dc.contributor.author | Hong, So-Hee | - |
dc.contributor.author | Seo, Young-Jin | - |
dc.date.accessioned | 2021-11-29T07:40:31Z | - |
dc.date.available | 2021-11-29T07:40:31Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51980 | - |
dc.description.abstract | Viral infectious diseases are a significant burden on public health and the global economy, and new viral threats emerge continuously. Since CD4(+) and CD8(+) T cell responses are essential to eliminating viruses, it is important to understand the underlying mechanisms of anti-viral T cell-mediated immunopathogenesis during viral infections. Remarkable progress in transgenic (Tg) techniques has enabled scientists to more readily understand the mechanisms of viral pathogenesis. T cell receptor (TCR) Tg mice are extremely useful in studying T cell-mediated immune responses because the majority of T cells in these mice express specific TCRs for partner antigens. In this review, we discuss the important studies utilizing TCR Tg mice to unveil underlying mechanisms of T cell-mediated immunopathogenesis during viral infections. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | TCR Transgenic Mice: A Valuable Tool for Studying Viral Immunopathogenesis Mechanisms | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms21249690 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.24, pp 1 - 12 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000602788700001 | - |
dc.identifier.scopusid | 2-s2.0-85098054747 | - |
dc.citation.endPage | 12 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 21 | - |
dc.type.docType | Review | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | TCR transgenic mice | - |
dc.subject.keywordAuthor | immunopathogenesis | - |
dc.subject.keywordAuthor | viral infection | - |
dc.subject.keywordAuthor | T cell | - |
dc.subject.keywordPlus | CD8+ T-CELLS | - |
dc.subject.keywordPlus | HERPES-SIMPLEX-VIRUS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | EFFECTOR CD4(+) | - |
dc.subject.keywordPlus | INFLUENZA | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | SELECTION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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