Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jang Won | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Lee, Jae Yong | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.date.accessioned | 2021-12-07T08:40:23Z | - |
dc.date.available | 2021-12-07T08:40:23Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52328 | - |
dc.description.abstract | The objectives of this study were (1) to fabricate ibuprofen-loaded porous microspheres (IBU/PMSs), (2) to evaluate the in vitro anti-inflammatory effects of the microspheres using LPS-induced inflammation in cultured synoviocytes, and (3) to evaluate the in vivo effect of the IBU/PMSs on the progression of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model. A dose-dependent in vitro anti-inflammatory effect on pro-inflammatory cytokine markers (matrix metallopeptidase-3 (MMP-3), matrix metallopeptidase-13 (MMP-13), cyclooxygenase-2 (COX-2), a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), interleukin-6 (IL-6), and tumor necrosis factor (TNF-alpha) was observed by confirming with real-time PCR analyses. In vivo, treatment with IBU/PMSs reduced MIA-stimulated mRNA expression of MMP-3, MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-alpha in rat synoviocytes. In addition, we demonstrated that intra-articular IBLI/PMSs suppressed the progression of MIA-induced OA in the rat model via anti-inflammatory mechanisms. In conclusion, IBU/PMSs are a promising therapeutic material to control the pain and progression of OA. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER | - |
dc.title | Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2016.07.050 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.147, pp 265 - 273 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000384851400031 | - |
dc.citation.endPage | 273 | - |
dc.citation.startPage | 265 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 147 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Ibuprofen | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | Porous microspheres | - |
dc.subject.keywordAuthor | Anti-inflammatory effect | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
dc.subject.keywordPlus | PLGA-MICROSPHERES | - |
dc.subject.keywordPlus | HYALURONIC-ACID | - |
dc.subject.keywordPlus | INTRAARTICULAR INJECTION | - |
dc.subject.keywordPlus | KNEE OSTEOARTHRITIS | - |
dc.subject.keywordPlus | COLLAGENASE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | HISTOPATHOLOGY | - |
dc.subject.keywordPlus | INTERLEUKIN-1 | - |
dc.subject.keywordPlus | SYNOVIOCYTES | - |
dc.subject.keywordPlus | CHONDROCYTES | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.