Anti-Obesity and Antidiabetic Effects of Nelumbinis Semen Powder in High-Fat Diet-Induced Obese C57BL/6 Mice
DC Field | Value | Language |
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dc.contributor.author | Hwang, Su Bin | - |
dc.contributor.author | Lee, Bog-Hieu | - |
dc.date.accessioned | 2021-12-16T00:41:02Z | - |
dc.date.available | 2021-12-16T00:41:02Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52464 | - |
dc.description.abstract | Nelumbinis Semen (NS, the seeds of Nelumbo nucifera) extract is a traditional Korean medicine with anti-oxidant activity. The present study examined the anti-obesity and antidiabetic effects of NS powder in high-fat diet (HFD)-induced obese C57BL/6 mice. Mice (n = 8/group) were fed a normal diet (CON), HFD, HFD containing 5% NS powder (HFD-NS5%), or HFD containing 10% NS powder (HFD-NS10%) for 12 weeks. Food intake was relatively higher in groups HFD-NS5% and HFD-NS10%, while the food efficiency ratio was highest in group HFD (p < 0.05). HFD-NS5% reduced the body weight (-39.1%) and fat weight (-26.6%), including epididymal fat and perirenal fat, and lowered the serum triglyceride levels (-20.6%) compared with HFD. Groups HFD-NS5% and HFD-NS10% showed hepatoprotective properties, reducing the serum ALT levels (p < 0.05) and fat globules (size and number) in the liver compared with group HFD. HFD-NS5% and HFD-NS10% regulated the blood glucose, improved the glucose intolerance, and showed a 12.5% and 15.0% reduction in the area under the curve (AUC) of intraperitoneal glucose tolerance test (IPGTT), and a 26.8% and 47.3% improvement in homeostatic model assessment insulin resistance (HOMA-IR), respectively, compared with HFD (p < 0.05). Regarding the expressions of genes related to anti-obesity and antidiabetes, there was a 1.7- and 1.3-fold increase in PPAR-alpha protein expression, 1.4- and 1.6-fold increase in PPAR-gamma protein expression, and 0.7- and 0.6-fold decrease in TNF-alpha protein expression, respectively, following HFD-NS5% and HFD-NS10% treatments, compared with HFD, and GLUT4 protein expression increased relative to CON (p < 0.05). These results comprehensively provide the fundamental data for NS powder's functional and health-promoting benefits associated with anti-obesity and antidiabetes. | - |
dc.format.extent | 18 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Anti-Obesity and Antidiabetic Effects of Nelumbinis Semen Powder in High-Fat Diet-Induced Obese C57BL/6 Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/nu12113576 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.12, no.11, pp 1 - 18 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000594524200001 | - |
dc.identifier.scopusid | 2-s2.0-85096440127 | - |
dc.citation.endPage | 18 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Nelumbinis Semen powder | - |
dc.subject.keywordAuthor | anti-obesity | - |
dc.subject.keywordAuthor | antidiabetes | - |
dc.subject.keywordAuthor | high-fat diet-induced obese mice | - |
dc.subject.keywordAuthor | PPAR-&#945 | - |
dc.subject.keywordAuthor | PPAR-&#947 | - |
dc.subject.keywordAuthor | GLUT4 | - |
dc.subject.keywordAuthor | TNF-&#945 | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | SEEDS | - |
dc.subject.keywordPlus | AMPK | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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