Osteoporotic Fractures of the Spine, Hip, and Other Locations after Adjuvant Endocrine Therapy with Aromatase Inhibitors in Breast Cancer Patients: a Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young-Kyun | - |
dc.contributor.author | Lee, Eun-Gyeong | - |
dc.contributor.author | Kim, Ha Young | - |
dc.contributor.author | Lee, Youjin | - |
dc.contributor.author | Lee, Seung-Mi | - |
dc.contributor.author | Suh, Dong-Churl | - |
dc.contributor.author | Yoo, Jun-Il | - |
dc.contributor.author | Lee, Seeyoun | - |
dc.date.accessioned | 2021-12-16T02:40:53Z | - |
dc.date.available | 2021-12-16T02:40:53Z | - |
dc.date.issued | 2020-11-30 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52498 | - |
dc.description.abstract | Background: Aromatase inhibitors (AIs) play an important role in the endocrine therapy of postmenopausal breast cancer patients, with a recent tendency to extend the duration of their use. However, AIs may increase the risk of osteoporotic bone fractures. This meta-analysis evaluated the risk of osteoporotic fractures of the hip, spine, and other locations in breast cancer patients using AIs. Methods: We performed a systematic search to identify randomized controlled clinical trials that investigated osteoporotic fractures in breast cancer patients on AI therapy. The main outcomes were the incidence and risk of osteoporotic fractures in general and of hip, vertebral, and non-vertebral fractures in AI users and controls. Results: The systematic review found a total of 30 randomized controlled trials including 117,974 participants. The meta-analysis showed a higher incidence of osteoporotic fracture in AI users: The crude risk ratio for all osteoporotic fractures was 1.35 (95% confidence interval [CI], 1.29-1.42; P < 0.001), for hip fractures 1.18 (95% CI, 1.02-1.35; P < 0.001), for vertebral fractures 1.84 (95% CI, 1.36-2.49; P < 0.001), and for non-vertebral fractures 1.18 (95% CI, 1.02-1.35; P < 0.001), respectively, compared to the controls. Conclusion: Our meta-analysis suggested an increased risk of osteoporotic fractures for AI therapy in patients with breast cancer that was most expressed for vertebral fractures. Breast cancer patients on AIs need to be monitored for osteoporosis and osteoporotic fractures, and active prevention measures should be implemented. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Osteoporotic Fractures of the Spine, Hip, and Other Locations after Adjuvant Endocrine Therapy with Aromatase Inhibitors in Breast Cancer Patients: a Meta-analysis | - |
dc.title.alternative | Osteoporotic Fractures of the Spine, Hip, and Other Locations after Adjuvant Endocrine Therapy with Aromatase Inhibitors in Breast Cancer Patients: a Meta-analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/jkms.2020.35.e403 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.35, no.46, pp 1 - 14 | - |
dc.identifier.kciid | ART002652401 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000595912100008 | - |
dc.identifier.scopusid | 2-s2.0-85097036959 | - |
dc.citation.endPage | 14 | - |
dc.citation.number | 46 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 35 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Aromatase Inhibitors | - |
dc.subject.keywordAuthor | Hip Fractures | - |
dc.subject.keywordAuthor | Breast Malignant Neoplasm | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Osteoporosis | - |
dc.subject.keywordAuthor | Post-menopausal | - |
dc.subject.keywordAuthor | Spinal Fractures | - |
dc.subject.keywordPlus | CONTINUED TAMOXIFEN TREATMENT | - |
dc.subject.keywordPlus | BONE-MINERAL DENSITY | - |
dc.subject.keywordPlus | PLUS ZOLEDRONIC ACID | - |
dc.subject.keywordPlus | POSTMENOPAUSAL WOMEN | - |
dc.subject.keywordPlus | RANDOMIZED-TRIAL | - |
dc.subject.keywordPlus | AMERICAN-SOCIETY | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | LETROZOLE | - |
dc.subject.keywordPlus | EXEMESTANE | - |
dc.subject.keywordPlus | ANASTROZOLE | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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