Phospholipid fraction has protective effect by improving inflammation and skin barrier function in ischemia-reperfusion injury in mice
DC Field | Value | Language |
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dc.contributor.author | Kim, S.-Y. | - |
dc.contributor.author | Kim, Y.-J. | - |
dc.contributor.author | Lee, E. | - |
dc.contributor.author | Choi, S.H. | - |
dc.contributor.author | Moon, J.S. | - |
dc.contributor.author | An, H.S. | - |
dc.contributor.author | Ji, E.S. | - |
dc.contributor.author | Na, J. | - |
dc.contributor.author | Kim, B.J. | - |
dc.date.accessioned | 2021-12-16T02:42:31Z | - |
dc.date.available | 2021-12-16T02:42:31Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2689-5293 | - |
dc.identifier.issn | 2689-5307 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52514 | - |
dc.description.abstract | The total phospholipid fraction (TPF) has anti-inflammatory properties and reduces apoptosis in animal models. Our objective was to assess the effects of TPF on pressure ulcers in a mouse model of cutaneous ischemic-reperfusion (I/R) injury. Cutaneous I/R injury was created by trapping the dorsal skin between two magnetic disks for 12 h, followed by disk removal. TPF administration in I/R areas at the beginning of reperfusion significantly inhibited the formation of pressure ulcers. The number of neutrophils and M1 macrophages and the levels of proinflammatory mediators MCP-1, IL-1β, IL-6, and TNF-α in the wound area were reduced upon TPF treatment. Collagen synthesis and α-SMA-positive microvessel density significantly increased in the wounds of TPF-treated mice. Additionally, TPF inhibited cutaneous I/R injury-induced formation and accumulation of apoptotic cells. Moreover, TPF increased the expression of filaggrin and involucrin. In conclusion, TPF may inhibit cutaneous I/R injury-induced formation of pressure ulcers by regulating inflammation, collagen production, angiogenesis, and skin barrier restoration. Therefore, exogenous application of TPF might have therapeutic potential with respect to cutaneous I/R injuries like decubitus ulcers. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Taylor and Francis Ltd. | - |
dc.title | Phospholipid fraction has protective effect by improving inflammation and skin barrier function in ischemia-reperfusion injury in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/26895293.2020.1838334 | - |
dc.identifier.bibliographicCitation | All Life, v.13, no.1, pp 623 - 633 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000618829100016 | - |
dc.identifier.scopusid | 2-s2.0-85094817797 | - |
dc.citation.endPage | 633 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 623 | - |
dc.citation.title | All Life | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | collagen | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | macrophages | - |
dc.subject.keywordAuthor | microvessel | - |
dc.subject.keywordAuthor | Phospholipid | - |
dc.subject.keywordAuthor | pressure ulcer | - |
dc.subject.keywordPlus | PRESSURE ULCERS | - |
dc.subject.keywordPlus | MACROPHAGE POLARIZATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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