Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Da-Seul | - |
dc.contributor.author | Lee, Jun-Kyu | - |
dc.contributor.author | Kim, Jun Hyuk | - |
dc.contributor.author | Lee, Jaemin | - |
dc.contributor.author | Kim, Dong Seon | - |
dc.contributor.author | An, Sanghyun | - |
dc.contributor.author | Park, Sung-Bin | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Rim, Jong Seop | - |
dc.contributor.author | Lee, Soonchul | - |
dc.contributor.author | Han, Dong Keun | - |
dc.date.accessioned | 2021-12-16T07:40:36Z | - |
dc.date.available | 2021-12-16T07:40:36Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52528 | - |
dc.description.abstract | Biodegradable polymers have been used with various systems for tissue engineering. Among them, poly(lactic-co-glycolic) acid (PLGA) has been widely used as a biomaterial for bone regeneration because of its great biocompatibility and biodegradability properties. However, there remain substantial cruxes that the by-products of PLGA result in an acidic environment at the implanting site, and the polymer has a weak mechanical property. In our previous study, magnesium hydroxide (MH) and bone extracellular matrix are combined with a PLGA scaffold (PME) to improve anti-inflammation and mechanical properties and osteoconductivity. In the present study, the development of a bioactive nanocomplex (NC) formed along with polydeoxyribonucleotide and bone morphogenetic protein 2 (BMP2) provides synergistic abilities in angiogenesis and bone regeneration. This PME hybrid scaffold immobilized with NC (PME/NC) achieves outstanding performance in anti-inflammation, angiogenesis, and osteogenesis. Such an advanced PME/NC scaffold suggests an integrated bone graft substitute for bone regeneration. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/sciadv.abj1083 | - |
dc.identifier.bibliographicCitation | SCIENCE ADVANCES, v.7, no.50 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000728174000011 | - |
dc.identifier.scopusid | 2-s2.0-85120827116 | - |
dc.citation.number | 50 | - |
dc.citation.title | SCIENCE ADVANCES | - |
dc.citation.volume | 7 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | DECELLULARIZED EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | MAGNESIUM-HYDROXIDE PARTICLES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.