Hyperthermal paclitaxel-bound albumin nanoparticles co-loaded with indocyanine green and hyaluronidase for treating pancreatic cancers
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Soo | - |
dc.contributor.author | Kim, Hwang Kyung | - |
dc.contributor.author | Kim, Hanju | - |
dc.contributor.author | Lee, Woo Tak | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.date.accessioned | 2021-12-22T01:41:39Z | - |
dc.date.available | 2021-12-22T01:41:39Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52674 | - |
dc.description.abstract | Albumin nanoparticles have become an attractive cancer nanomedicine platform due to their pharmaceutical advantages. Recently, photothermal therapy has been extensively applied to cancer treatment due to heat-induced tumor ablation. Herein, we fabricated albumin nanoparticles (HSA-NPs) loaded with paclitaxel (PTX), indocyanine green (ICG; a hyperthermal agent) and hyaluronidase (HAase) that breaks down hyaluronan, a major component of the extracellular matrix (ECM) in tumors. Synthesis was based on a slightly modified nanoparticle albumin-bound (Nab (TM)) technique. The prepared nanoparticles (PTX/ICG/HAase-HSA-NPs) had a spherical shape with an average size of similar to 110 nm and a zeta potential of similar to -30.4 mV. They displayed good colloidal stability and typical patterns of ICG, HSA and HAase in UV-VIS-NIR and circular dichroism spectroscopic analysis. PTX/ICG/HAase-HSA-NPs were found to have excellent hyperthermal effects in response to near-infrared laser irradiation (808 nm) (up to > 50 degrees C over 4 min). The hyperthermia conducted by PTX/ICG/HAase-HSA-NPs resulted in significant cytotoxicity to pancreatic AsPC-1 cells at both severe (> 50 degrees C) and mild (41-42 degrees C) hyperthermal states in conjunction with the inherent cytotoxic activity of paclitaxel. Furthermore, the confocal images of AsPC-1 cell spheroids proved PTX/ICG/HAase-HSA-NPs were able to permeate deeply into the three-dimensional tumor tissue mimicry structure. Most of all, PTX/ICG/HAase-HSA-NPs maintained all these physicochemical and anti-cancer properties irrespective of the amount of embedded HAase (1-5 mg). Our results demonstrated that PTX/ICG/HAase-HSA-NPs are a promising hyperthermal/chemotherapeutic anticancer agent. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Hyperthermal paclitaxel-bound albumin nanoparticles co-loaded with indocyanine green and hyaluronidase for treating pancreatic cancers | - |
dc.title.alternative | Hyperthermal paclitaxel-bound albumin nanoparticles co-loaded with indocyanine green and hyaluronidase for treating pancreatic cancers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12272-020-01264-9 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.44, no.2, pp 182 - 193 | - |
dc.identifier.kciid | ART002689937 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000560277500001 | - |
dc.identifier.scopusid | 2-s2.0-85089480835 | - |
dc.citation.endPage | 193 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 182 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 44 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Indocyanine green | - |
dc.subject.keywordAuthor | Hyaluronidase | - |
dc.subject.keywordAuthor | Hyperthermal therapy | - |
dc.subject.keywordAuthor | Albumin nanoparticles | - |
dc.subject.keywordAuthor | Tumor targeting | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | ICG | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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