Functional cross-talk between p73 beta and NF-kappa B mediated by p300
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryou, Sang-Mi | - |
dc.contributor.author | Kang, Kyung-Hwa | - |
dc.contributor.author | Jeong, Mi-Hee | - |
dc.contributor.author | Kim, Jung Woong | - |
dc.contributor.author | An, Joo-Hee | - |
dc.contributor.author | Lee, So-Youn | - |
dc.contributor.author | Jang, Sangmin | - |
dc.contributor.author | Song, Peter I. | - |
dc.contributor.author | Choi, Kyung-Hee | - |
dc.date.accessioned | 2021-12-24T01:42:05Z | - |
dc.date.available | 2021-12-24T01:42:05Z | - |
dc.date.issued | 2006-06 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52732 | - |
dc.description.abstract | p73 beta is associated with induction of apoptosis or cellular growth arrest, while NF-kappa B is closely related with promotion of resistance to programmed cell death. These biologically opposing activities between p73 beta and NF-kappa B propose a regulatory mechanism of critical turning on/off in cellular apoptotic or survival responses. In this study, we demonstrate that NF-kappa B-mediated transactivation is specifically downreaulated by p73 beta; conversely, p73 beta-transactivation is negatively regulated by functional expression of p65, NF-kappa B RelA subunit. The p73 beta transactivation domain (TA) and p65 NH-terminus are crucial for their negative regulation of p65- and p73 beta-mediated transactivation, respectively. Furthermore, p65- or p73 beta-interaction with p300 is reciprocally inhibited by their competitive binding to p300 in a restrict amount-dependent manner. Likewise, both p73 beta-activated apoptosis and p65-dependent increase of cell viability Lire reciprocally repressed by p65 and p73 beta, respectively. These results have important implications for p300-mediated regulatory mechanism between p73 beta- and p65-transactivation, by which both p73 beta and NF-kappa B could Mutually affect on their biological activities. Therefore, we propose that p300 is a transactivational regulator of competitively balanced cross-talk between p73 beta and p65. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Functional cross-talk between p73 beta and NF-kappa B mediated by p300 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.04.120 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.345, no.2, pp 623 - 630 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000238001600012 | - |
dc.citation.endPage | 630 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 623 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 345 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | p73 | - |
dc.subject.keywordAuthor | NF-kappa B RelA(p65) | - |
dc.subject.keywordAuthor | p300 | - |
dc.subject.keywordPlus | CREB-BINDING PROTEIN | - |
dc.subject.keywordPlus | P53 FAMILY-MEMBER | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVATION | - |
dc.subject.keywordPlus | P73 | - |
dc.subject.keywordPlus | ACETYLATION | - |
dc.subject.keywordPlus | INTEGRATOR | - |
dc.subject.keywordPlus | P63 | - |
dc.subject.keywordPlus | CBP | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.