Calcium-binding near-infrared fluorescent nanoprobe for bone tissue imaging
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Y.G. | - |
dc.contributor.author | Kim, H.J. | - |
dc.contributor.author | Kim, J.W. | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.date.accessioned | 2022-01-04T02:40:28Z | - |
dc.date.available | 2022-01-04T02:40:28Z | - |
dc.date.issued | 2020-09-25 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52868 | - |
dc.description.abstract | We report a self-assembled calcium-binding nanoprobe which emits a near-infrared fluorescence (NIRF) signal. We have designed a calcium-binding NIRF nanoprobe by chemically coupling alendronate (ALN), a specific targeting ligand, and NIRF-emitting Cy5.5-labeled dibenzocyclooctyne, to the two respective ends of azide-polyethylene glycol-NHS ester. Prepared ALN-PEG-Cy5.5 forms the self-assembled nanostructures and has high affinity for calcium phosphates-containing bone minerals. In addition, ALN-PEG-Cy5.5 can be employed to visualize intracellular calcium ion levels in vitro as well as normal bone tissues in vivo. These results suggest that our calcium-binding NIRF nanoprobe has a promising potential for calcium imaging in vitro and in vivo. © 2020 The Korean Society of Industrial and Engineering Chemistry | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Industrial Engineering Chemistry | - |
dc.title | Calcium-binding near-infrared fluorescent nanoprobe for bone tissue imaging | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jiec.2020.06.018 | - |
dc.identifier.bibliographicCitation | Journal of Industrial and Engineering Chemistry, v.89, pp 442 - 447 | - |
dc.identifier.kciid | ART002626601 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000552706400044 | - |
dc.identifier.scopusid | 2-s2.0-85087286374 | - |
dc.citation.endPage | 447 | - |
dc.citation.startPage | 442 | - |
dc.citation.title | Journal of Industrial and Engineering Chemistry | - |
dc.citation.volume | 89 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Alendronate | - |
dc.subject.keywordAuthor | Bone tissue imaging | - |
dc.subject.keywordAuthor | Calcium-binding nanoprobe | - |
dc.subject.keywordAuthor | Copper-free click chemistry | - |
dc.subject.keywordAuthor | Intracellular calcium detection | - |
dc.subject.keywordPlus | Calcium phosphate | - |
dc.subject.keywordPlus | Fluorescence | - |
dc.subject.keywordPlus | Nanoprobes | - |
dc.subject.keywordPlus | Tissue | - |
dc.subject.keywordPlus | Calcium binding | - |
dc.subject.keywordPlus | Calcium imaging | - |
dc.subject.keywordPlus | High affinity | - |
dc.subject.keywordPlus | Intracellular calcium | - |
dc.subject.keywordPlus | Near-infrared fluorescence | - |
dc.subject.keywordPlus | Near-infrared fluorescent | - |
dc.subject.keywordPlus | Self assembled nanostructures | - |
dc.subject.keywordPlus | Targeting ligands | - |
dc.subject.keywordPlus | Infrared devices | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.