Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural-molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery
DC Field | Value | Language |
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dc.contributor.author | Kim, Sunwon | - |
dc.contributor.author | Lee, Min Woo | - |
dc.contributor.author | Kim, Tae Shik | - |
dc.contributor.author | Song, Joon Woo | - |
dc.contributor.author | Nam, Hyeong Soo | - |
dc.contributor.author | Cho, Han Saem | - |
dc.contributor.author | Jang, Sun-Joo | - |
dc.contributor.author | Ryu, Jiheun | - |
dc.contributor.author | Oh, Dong Joo | - |
dc.contributor.author | Gweon, Dae-Gab | - |
dc.contributor.author | Park, Seong Hwan | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Oh, Wang-Yuhl | - |
dc.contributor.author | Yoo, Hongki | - |
dc.contributor.author | Kim, Jin Won | - |
dc.date.accessioned | 2022-01-04T05:40:36Z | - |
dc.date.available | 2022-01-04T05:40:36Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0195-668X | - |
dc.identifier.issn | 1522-9645 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52896 | - |
dc.description.abstract | Aims Inflammation plays essential role in development of plaque disruption and coronary stent-associated complications. This study aimed to examine whether intracoronary dual-modal optical coherence tomography (OCT)-near-infrared fluorescence (NIRF) structural-molecular imaging with indocyanine green (ICG) can estimate inflammation in swine coronary artery. Methods and results After administration of clinically approved NIRF-enhancing ICG (2.0 mg/kg) or saline, rapid coronary imaging (20 mm/s pullback speed) using a fully integrated OCT-NIRF catheter was safely performed in 12 atheromatous Yucatan minipigs and in 7 drug-eluting stent (DES)-implanted Yorkshire pigs. Stronger NIRF activity was identified in OCT-proven high-risk plaque compared to normal or saline-injected controls (P = 0.0016), which was validated on ex vivo fluorescence reflectance imaging. In vivo plaque target-to-background ratio (pTBR) was much higher in inflamed lipid-rich plaque compared to fibrous plaque (P < 0.0001). In vivo and ex vivo peak pTBRs correlated significantly (P < 0.0022). In vitro cellular ICG uptake and histological validations corroborated the OCT-NIRF findings in vivo. Indocyanine green colocalization with macrophages and lipids of human plaques was confirmed with autopsy atheroma specimens. Two weeks after DES deployment, OCT-NIRF imaging detected strong NIRF signals along stent struts, which was significantly higher than baseline (P = 0.0156). Histologically, NIRF signals in peri-strut tissue co-localized well with macrophages. Conclusion The OCT-NIRF imaging with a clinical dose of ICG was feasible to accurately assess plaque inflammation and DES-related inflammation in a beating coronary artery. This highly translatable dual-modal molecular-structural imaging strategy could be relevant for clinical intracoronary estimation of high-risk plaques and DES biology. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural-molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/eurheartj/ehv726 | - |
dc.identifier.bibliographicCitation | EUROPEAN HEART JOURNAL, v.37, no.37, pp 2833 - 2844 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000387004400012 | - |
dc.citation.endPage | 2844 | - |
dc.citation.number | 37 | - |
dc.citation.startPage | 2833 | - |
dc.citation.title | EUROPEAN HEART JOURNAL | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Imaging | - |
dc.subject.keywordAuthor | Plaque | - |
dc.subject.keywordAuthor | Stents | - |
dc.subject.keywordPlus | ATHEROSCLEROTIC PLAQUES | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | RESTENOSIS | - |
dc.subject.keywordPlus | CATHETER | - |
dc.subject.keywordPlus | OCT | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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