Cardiovascular and Gastrointestinal Effects of Etoricoxib in the Treatment of Osteoarthritis: A Systematic Review and Network Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Kim, Dam | - |
dc.contributor.author | Cho, Soo-Kyung | - |
dc.contributor.author | Nam, Seoung Wan | - |
dc.contributor.author | Kwon, Hyuk Hee | - |
dc.contributor.author | Jung, Sun-Young | - |
dc.contributor.author | Jeon, Chan Hong | - |
dc.contributor.author | Im, Seul Gi | - |
dc.contributor.author | Kim, Dalho | - |
dc.contributor.author | Jang, Eun Jin | - |
dc.contributor.author | Sung, Yoon-Kyoung | - |
dc.date.available | 2019-03-08T10:36:09Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2093-940X | - |
dc.identifier.issn | 2233-4718 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/5326 | - |
dc.description.abstract | Objective. To estimate the cardiovascular (CV) and gastrointestinal (GI) risks of etoricoxib in the treatment of osteoarthritis (OA) compared to a placebo and other non-steroidal anti-inflammatory drugs (NSAIDs). Methods. A systematic review of randomized, controlled trials (RCTs) of etoricoxib were performed. Bayesian network meta-analysis was used over a duration of 12 weeks. The incidence of CV and GI events for a duration ≥26 weeks were also tabulated and presented using descriptive statistics. Results. From this search, 10 studies were identified. Of these, 6 and 5 RCTs that measured the CV and GI events at 12 weeks were included in meta-analysis. They showed that etoricoxib did not increase the CV events compared to the placebo or NSAIDs during the 12 week period (odds ratio [OR]=0.59 compared to celecoxib, OR=0.89 with ibuprofen, OR=0.70 with placebo, and OR=2.16 with naproxen). The risk of GI events was comparable to that of most comparators, with the exception of naproxen, which had a significantly lower risk of GI events (OR=0.18) during the 12 week period. For a duration ≥26 weeks, the incidence of CV and GI events with etoricoxib increased with increasing duration. Conclusion. Etoricoxib is an alternative short-term treatment option for OA, showing comparable CV and GI complications to other NSAIDs. Nevertheless, further studies will be needed to elucidate the long-term safety of etoricoxib in the treatment of OA. | - |
dc.format.extent | 10 | - |
dc.publisher | 대한류마티스학회 | - |
dc.title | Cardiovascular and Gastrointestinal Effects of Etoricoxib in the Treatment of Osteoarthritis: A Systematic Review and Network Meta-analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.4078/jrd.2017.24.5.293 | - |
dc.identifier.bibliographicCitation | 대한류마티스학회지, v.24, no.5, pp 293 - 302 | - |
dc.identifier.kciid | ART002276656 | - |
dc.description.isOpenAccess | Y | - |
dc.citation.endPage | 302 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 293 | - |
dc.citation.title | 대한류마티스학회지 | - |
dc.citation.volume | 24 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Anti-inflammatory agents | - |
dc.subject.keywordAuthor | non-steroidal | - |
dc.subject.keywordAuthor | Etoricoxib | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
dc.subject.keywordAuthor | Safety | - |
dc.description.journalRegisteredClass | kci | - |
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