Anti-Inflammatory Effects of Fermented Bark of Acanthopanax sessiliflorus and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Ji | - |
dc.contributor.author | Wang, Hye Soo | - |
dc.contributor.author | Lee, Min Won | - |
dc.date.accessioned | 2022-01-13T05:41:26Z | - |
dc.date.available | 2022-01-13T05:41:26Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.issn | 1741-4288 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53467 | - |
dc.description.abstract | The fermentation was carried out on the bark ofAcanthopanax sessiliflorus(AS).Acanthopanaxspecies have been used in traditional medicine as tonics, sedatives, and antispasmodics. An activity-guided isolation of the fermented bark ofA. sessiliflorus(FAS) yielded several phytochemicals: acanthoside D (1), acanthoside B (2), daucosterol (3), protocatechuic acid (4), chlorogenic acid methyl ester (5), ciwujiatone (6), syringaresinol (7), farnesol (8), 3,4-dicaffeoylquinic acid (9), and falcarindiol (10). HPLC analysis showed that content of lignan glycoside (1)was decreased and4and7were increased after fermentation. Anti-inflammatory activities on FAS showed the decrease of nitric oxide (NO) production, and inhibitory activities of iNOS and COX-2, proinflammatory cytokines (IL-6 and tumor necrosis factor-alpha), and collagenase. The aglycone, syringaresinol (7), which was increased through fermentation showed enhanced activity than1. Thus, FAS may have the potential to treat inflammatory disorders, such as arthritis. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | HINDAWI LTD | - |
dc.title | Anti-Inflammatory Effects of Fermented Bark of Acanthopanax sessiliflorus and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1155/2020/6749425 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2020 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000559125900004 | - |
dc.identifier.scopusid | 2-s2.0-85089309826 | - |
dc.citation.title | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 2020 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | PROTOCATECHUIC ACID | - |
dc.subject.keywordPlus | PHENOLIC-COMPOUNDS | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | SAPONINS | - |
dc.subject.keywordPlus | FRUITS | - |
dc.subject.keywordPlus | STEMS | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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