Exosomal microRNA expression profiles of cerebrospinal fluid in febrile seizure patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Seh Hyun | - |
dc.contributor.author | Yun, Sin-Weon | - |
dc.contributor.author | Kim, Hye Ryoun | - |
dc.contributor.author | Chae, Soo Ahn | - |
dc.date.accessioned | 2022-01-13T06:40:48Z | - |
dc.date.available | 2022-01-13T06:40:48Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1059-1311 | - |
dc.identifier.issn | 1532-2688 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53478 | - |
dc.description.abstract | Purpose: Febrile seizures (FS) are the most common seizures found in pediatric patients. Recently, microRNA (miRNA) have been used as a novel biomarker for the diagnosis of various diseases. This study aims to explore the exosomal miRNA expression profile of the cerebrospinal fluid (CSF) in atypical FS patients. Methods: This is a case-control study including CSF specimens of 41 pediatric patients. The CSF specimens were categorized into FS and a control group. Microarray assays were performed to evaluate the CSF exosomal miRNA expression profile. Quantitative PCR (qPCR) assays were conducted to validate the microarray assay result. Bioinformatic analysis was performed to analyze the result. Results: Thirteen (62%) patients in the FS group experienced complex FS. A total of 96 miRNAs were significantly expressed in the CSF study samples and 95 amongst them, exhibited higher expression in FS than in the control group. Further validation qPCR test indicated that the top 5 highly expressed miRNA (miR-4486, miR-6850-5p, miR-642b-3p, miR-7107-5p, miR-4281) showed same results as in the microarray assay. Bioinformatic analysis identified 455 target genes in the FS group. Conclusion: FS patients displayed higher CSF exosomal miRNA profiles than the control. These altered miRNA profiles appeared to be related to complex FS. © 2020 British Epilepsy Association | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | W.B. Saunders Ltd | - |
dc.title | Exosomal microRNA expression profiles of cerebrospinal fluid in febrile seizure patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.seizure.2020.07.015 | - |
dc.identifier.bibliographicCitation | Seizure, v.81, pp 47 - 52 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000583710200009 | - |
dc.identifier.scopusid | 2-s2.0-85088637105 | - |
dc.citation.endPage | 52 | - |
dc.citation.startPage | 47 | - |
dc.citation.title | Seizure | - |
dc.citation.volume | 81 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | cerebrospinal fluid | - |
dc.subject.keywordAuthor | exosome | - |
dc.subject.keywordAuthor | febrile seizure | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordPlus | microRNA | - |
dc.subject.keywordPlus | microRNA 1249 3p | - |
dc.subject.keywordPlus | microRNA 1268b | - |
dc.subject.keywordPlus | microRNA 188 5p | - |
dc.subject.keywordPlus | microRNA 1915 3p | - |
dc.subject.keywordPlus | microRNA 3162 5p | - |
dc.subject.keywordPlus | microRNA 3656 | - |
dc.subject.keywordPlus | microRNA 4270 | - |
dc.subject.keywordPlus | microRNA 4271 | - |
dc.subject.keywordPlus | microRNA 4281 | - |
dc.subject.keywordPlus | microRNA 4486 | - |
dc.subject.keywordPlus | microRNA 4507 | - |
dc.subject.keywordPlus | microRNA 5739 | - |
dc.subject.keywordPlus | microRNA 6089 | - |
dc.subject.keywordPlus | microRNA 6124 | - |
dc.subject.keywordPlus | microRNA 6127 | - |
dc.subject.keywordPlus | microRNA 6165 | - |
dc.subject.keywordPlus | microRNA 642a 3p | - |
dc.subject.keywordPlus | microRNA 642b 3p | - |
dc.subject.keywordPlus | microRNA 6741 | - |
dc.subject.keywordPlus | microRNA 6749 5p | - |
dc.subject.keywordPlus | microRNA 6800 5p | - |
dc.subject.keywordPlus | microRNA 6803 5p | - |
dc.subject.keywordPlus | microRNA 6821 5p | - |
dc.subject.keywordPlus | microRNA 6850 5p | - |
dc.subject.keywordPlus | microRNA 6869 5p | - |
dc.subject.keywordPlus | microRNA 6879 5p | - |
dc.subject.keywordPlus | microRNA 7107 5p | - |
dc.subject.keywordPlus | microRNA 7110 5p | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | unindexed drug | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | bioinformatics | - |
dc.subject.keywordPlus | case control study | - |
dc.subject.keywordPlus | cerebrospinal fluid | - |
dc.subject.keywordPlus | cerebrospinal fluid analysis | - |
dc.subject.keywordPlus | child | - |
dc.subject.keywordPlus | clinical article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | exosome | - |
dc.subject.keywordPlus | febrile convulsion | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gene expression profiling | - |
dc.subject.keywordPlus | gene targeting | - |
dc.subject.keywordPlus | hemoglobin blood level | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | leukocyte count | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | microarray analysis | - |
dc.subject.keywordPlus | neutrophil count | - |
dc.subject.keywordPlus | polymerase chain reaction | - |
dc.subject.keywordPlus | preschool child | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | quantitative analysis | - |
dc.subject.keywordPlus | RNA analysis | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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