Protective effects of protocatechuic acid against cognitive impairment in an amyloid beta-induced Alzheimer's disease mouse model
DC Field | Value | Language |
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dc.contributor.author | Choi, J.R. | - |
dc.contributor.author | Kim, J.H. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Cho, E.J. | - |
dc.contributor.author | Kim, H.Y. | - |
dc.date.accessioned | 2022-01-13T06:40:54Z | - |
dc.date.available | 2022-01-13T06:40:54Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.issn | 1873-6351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53479 | - |
dc.description.abstract | In this study, we investigated the protective effects of protocatechuic acid (PA) against cognitive impairment in an amyloid-beta (Aβ)-induced Alzheimer's disease (AD) mouse model. PA was administered orally for 14 days at 100 and 200 mg/kg/day. To examine effects on cognition, we conducted behavior tests including the T-maze test, novel object recognition, and the Morris water maze test. In addition, we measured lipid peroxidation, nitric oxide (NO) production, and inflammation-related protein expression in mice tissues. The PA-administered group showed more use of novel routes, better novel object recognition, and learning and memory ability compared to the Aβ25-35-injected mice in the behavior tests. The results indicated that the administration of higher PA protected against cognitive impairment. In addition, the PA-administered groups showed significantly decreased lipid peroxidation and NO production in the brain, kidney, and liver tissues. Furthermore, the PA-administered groups showed attenuated Aβ25-35-induced neuroinflammation by downregulating inflammatory mediators, inducible nitric oxide synthase and cyclooxygenase-2 in the brain. The results of the present study suggest that PA may be a protective agent against AD. © 2020 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Protective effects of protocatechuic acid against cognitive impairment in an amyloid beta-induced Alzheimer's disease mouse model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fct.2020.111571 | - |
dc.identifier.bibliographicCitation | Food and Chemical Toxicology, v.144 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000566815000006 | - |
dc.identifier.scopusid | 2-s2.0-85088659565 | - |
dc.citation.title | Food and Chemical Toxicology | - |
dc.citation.volume | 144 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Alzheimer's disease | - |
dc.subject.keywordAuthor | Amyloid-beta | - |
dc.subject.keywordAuthor | Neuroinflammation | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Protocatechuic acid | - |
dc.subject.keywordPlus | amyloid beta protein[25-35] | - |
dc.subject.keywordPlus | cyclooxygenase 2 | - |
dc.subject.keywordPlus | cytokine | - |
dc.subject.keywordPlus | inducible nitric oxide synthase | - |
dc.subject.keywordPlus | inflammatory mediator | - |
dc.subject.keywordPlus | nitric oxide | - |
dc.subject.keywordPlus | protocatechuic acid | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | Alzheimer disease | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | brain tissue | - |
dc.subject.keywordPlus | cognition | - |
dc.subject.keywordPlus | cognitive defect | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | down regulation | - |
dc.subject.keywordPlus | drug dose comparison | - |
dc.subject.keywordPlus | drug effect | - |
dc.subject.keywordPlus | inflammation | - |
dc.subject.keywordPlus | kidney tissue | - |
dc.subject.keywordPlus | learning | - |
dc.subject.keywordPlus | lipid peroxidation | - |
dc.subject.keywordPlus | liver tissue | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | memory | - |
dc.subject.keywordPlus | Morris water maze test | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | mouse model | - |
dc.subject.keywordPlus | nervous system inflammation | - |
dc.subject.keywordPlus | neuroprotection | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | novel object recognition test | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | T-maze test | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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