Coassembled Nanoparticles Composed of Functionalized Mesoporous Silica and Pillar[5]arene-Appended Gold Nanoparticles as Mitochondrial-Selective Dual-Drug Carriers
DC Field | Value | Language |
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dc.contributor.author | Ahn, Junho | - |
dc.contributor.author | Jin, Hanyong | - |
dc.contributor.author | Park, Jaehyeon | - |
dc.contributor.author | Lee, Boeun | - |
dc.contributor.author | Ok, Mirae | - |
dc.contributor.author | Lee, Ji Ha | - |
dc.contributor.author | Bae, Jeehyeon | - |
dc.contributor.author | Jung, Jong Hwa | - |
dc.date.accessioned | 2022-01-14T02:41:28Z | - |
dc.date.available | 2022-01-14T02:41:28Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 0934-0866 | - |
dc.identifier.issn | 1521-4117 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53554 | - |
dc.description.abstract | Coassembled nanoparticles composed of functionalized mesoporous silica and pillar[5]arene-appended Au nanoparticles obtained through the formation of a host-guest complex are designed and synthesized as a mitochondrial-selective dual-drug delivery system. A pyridinium-based ligand and fluorescein isothiocyanate are immobilized onto mesoporous silica to act as the mitochondria-targeting ligand and fluorescence tracker, respectively, of a material dubbed NP-3. Carboxylated pillar[5]arene-capped Au nanoparticles (CP-AuNPs) are fabricated by the templated reduction of Au3+. Interestingly, coassembled nanoparticles (NP-1) composed of doxorubicin (DOX) loaded NP-3 and CP-AuNPs are then prepared via the formation of a host-guest complex between the pyridinium-based ligand of NP-3 and the pillar[5]arene of CP-AuNPs. To demonstrate the effectiveness of NP-2 and NP-1 as mitochondrial targeting drug delivery systems, DOX and F16 are employed as model drugs. These drugs loaded onto NP-2 and CP-AuNPs, respectively, are selectively delivered to mitochondria, indicating the usefulness of NP-2 and CP-AuNPs as mitochondrial-specific drug-delivery carriers in cancer cells. More interestingly, the use of NP-1 is also associated with the selective accumulation of DOX and F16 in mitochondria. The selective mitochondrial-targeting of NP-1 is possible by NP-2 and F16 exposed to the cytoplasm, allowing the codelivery of the two drugs to the mitochondria. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Coassembled Nanoparticles Composed of Functionalized Mesoporous Silica and Pillar[5]arene-Appended Gold Nanoparticles as Mitochondrial-Selective Dual-Drug Carriers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ppsc.202000136 | - |
dc.identifier.bibliographicCitation | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, v.37, no.9 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000553779200001 | - |
dc.identifier.scopusid | 2-s2.0-85088782987 | - |
dc.citation.number | 9 | - |
dc.citation.title | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | coassembled nanoparticles | - |
dc.subject.keywordAuthor | codelivery | - |
dc.subject.keywordAuthor | mitochondrial targeting | - |
dc.subject.keywordAuthor | nanocarriers | - |
dc.subject.keywordAuthor | pillar[5]arene | - |
dc.subject.keywordAuthor | silica | - |
dc.subject.keywordAuthor | Au nanoparticle composites | - |
dc.subject.keywordPlus | THERAPY IN-VITRO | - |
dc.subject.keywordPlus | ANTICANCER DRUG | - |
dc.subject.keywordPlus | MOLECULAR TRANSPORTERS | - |
dc.subject.keywordPlus | TARGETED DELIVERY | - |
dc.subject.keywordPlus | GUANIDINIUM-RICH | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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