IFITM proteins inhibit the late step of feline foamy virus replication
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jinsun | - |
dc.contributor.author | Shin, Cha-Gyun | - |
dc.date.accessioned | 2022-01-18T02:41:25Z | - |
dc.date.available | 2022-01-18T02:41:25Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1976-8354 | - |
dc.identifier.issn | 2151-2485 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53690 | - |
dc.description.abstract | Interferon-induced transmembrane (IFITM) proteins as host restriction factors are known to inhibit the replication of several viruses. In this study, transient IFITM expression vectors were used to investigate whether IFITMs inhibit feline foamy viral (FFV) replication and which step of viral replication is inhibited. In our studies, viral production was significantly reduced when cells were infected with FFV at almost same times such as -3, 0, or 3 h post-transfection with IFITM vector. However viral production was not reduced even though cells were infected with FFV at 3 or 6 days post-transfection when production of IFITM proteins was maximized. Considering that IFITM expression was maximized at 3 days post-transfection, the stage of viral replication inhibited by IFITM appears to be the late step of viral replication. Moreover, the viral Gag proteins detected in the virus-infected cell lysates were proportionally correlated with viral titer of the culture supernatants. Therefore, it is likely that IFITMs can restrict production of FFV at the late step of viral replication. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | IFITM proteins inhibit the late step of feline foamy virus replication | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/19768354.2020.1819413 | - |
dc.identifier.bibliographicCitation | ANIMAL CELLS AND SYSTEMS, v.24, no.5, pp 282 - 288 | - |
dc.identifier.kciid | ART002642503 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000569447600001 | - |
dc.identifier.scopusid | 2-s2.0-85091114665 | - |
dc.citation.endPage | 288 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 282 | - |
dc.citation.title | ANIMAL CELLS AND SYSTEMS | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | IFITM | - |
dc.subject.keywordAuthor | feline foamy virus | - |
dc.subject.keywordAuthor | late step | - |
dc.subject.keywordPlus | INDUCED TRANSMEMBRANE PROTEINS | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.