Concomitant use of nsaids or ssris with noacs requires monitoring for bleeding
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Min-Taek | - |
dc.contributor.author | Park, Kwang-Yeol | - |
dc.contributor.author | Kim, Myo-Song | - |
dc.contributor.author | You, Seung-Hun | - |
dc.contributor.author | Kang, Ye-Jin | - |
dc.contributor.author | Jung, Sun-Young | - |
dc.date.accessioned | 2022-01-18T02:41:56Z | - |
dc.date.available | 2022-01-18T02:41:56Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.issn | 1976-2437 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53696 | - |
dc.description.abstract | Purpose: Non-vitamin K antagonist oral anticoagulants (NOACs) are widely used in patients with atrial fibrillation (AF) because of their effectiveness in preventing stroke and their better safety, compared with warfarin. However, there are concerns for an increased risk of bleeding associated with concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) or selective sero-tonin reuptake inhibitors (SSRIs) with NOACs. In this study, we aimed to evaluate the risk of bleeding events in individuals taking concomitant NSAIDs or SSRIs with NOACs after being diagnosed with AF. Materials and Methods: A nested case-control analysis to assess the safety of NSAIDs and SSRIs among NOAC users with AF was performed using data from Korean National Health Insurance Service from January 2012 to December 2017. Among patients who were newly prescribed NOACs, 1233 cases hospitalized for bleeding events were selected, and 24660 controls were determined. Results: The risk of bleeding events was higher in patients receiving concomitant NSAIDs [adjusted odds ratio (aOR) 1.41; 95% confidence interval (CI) 1.24–1.61] or SSRIs (aOR 1.92; 95% CI 1.52–2.42) with NOACs, compared to no use of either drug, respectively. The risk of upper gastrointestinal bleeding was higher in patients receiving concomitant NSAIDs or SSRIs without proton pump inhibitors (PPIs) (NSAIDs: aOR 2.47; 95% CI 1.26–4.83, SSRI: aOR 10.8; 95% CI 2.41–2.48) compared to no use. Conclusion: When NSAIDs or SSRIs are required for NOAC users with AF, physicians need to monitor bleeding events and con-sider the use of PPIs, especially for combined use of both drugs or when initiating NOACs treatment. © Yonsei University College of Medicine 2020. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Yonsei University College of Medicine | - |
dc.title | Concomitant use of nsaids or ssris with noacs requires monitoring for bleeding | - |
dc.type | Article | - |
dc.identifier.doi | 10.3349/ymj.2020.61.9.741 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, v.61, no.9, pp 741 - 749 | - |
dc.identifier.kciid | ART002615835 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000573503600002 | - |
dc.identifier.scopusid | 2-s2.0-85090321022 | - |
dc.citation.endPage | 749 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 741 | - |
dc.citation.title | Yonsei Medical Journal | - |
dc.citation.volume | 61 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Atrial fibrillation | - |
dc.subject.keywordAuthor | Drug interactions | - |
dc.subject.keywordAuthor | Hemorrhages | - |
dc.subject.keywordAuthor | Nested case-control study | - |
dc.subject.keywordAuthor | Non-vitamin K antagonist oral anticoagulants | - |
dc.subject.keywordPlus | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject.keywordPlus | SEROTONIN REUPTAKE INHIBITORS | - |
dc.subject.keywordPlus | ATRIAL-FIBRILLATION | - |
dc.subject.keywordPlus | ORAL ANTICOAGULANTS | - |
dc.subject.keywordPlus | PLATELET-FUNCTION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CLOPIDOGREL | - |
dc.subject.keywordPlus | AGENTS | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.