Antiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cells
DC Field | Value | Language |
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dc.contributor.author | Lim, Sooyeon | - |
dc.contributor.author | Ahn, Jin-Chul | - |
dc.contributor.author | Lee, Eun Jin | - |
dc.contributor.author | Kim, Jongkee | - |
dc.date.accessioned | 2022-01-19T04:48:54Z | - |
dc.date.available | 2022-01-19T04:48:54Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2468-0834 | - |
dc.identifier.issn | 2468-0842 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53869 | - |
dc.description.abstract | Sulforaphene (SFE), a major isothiocyanate in radish seeds, is a close chemical relative of sulforaphane (SFA) isolated from broccoli seeds and florets. The anti-proliferative mechanisms of SFA against cancer cells have been well investigated, but little is known about the potential anti-proliferative effects of SFE. In this study, we showed that SFE purified from radish seeds inhibited the growth of six cancer cell lines (A549, CHO, HeLa, Hepa1c1c7, HT-29, and LnCaP), with relative half maximal inhibitory concentration values ranging from 1.37 to 3.31 mu g/mL. Among the six cancer cell lines, SFE showed the greatest growth inhibition against A549 lung cancer cells, where it induced apoptosis by changing the levels of poly(ADP-ribose) polymerase and caspase-3, -8, and -9. Our results indicate that SFE from radish seeds may have significant anti-proliferative potency against a broad range of human cancer cells via induction of apoptosis. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER SINGAPORE PTE LTD | - |
dc.title | Antiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cells | - |
dc.title.alternative | Antiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13765-020-00561-7 | - |
dc.identifier.bibliographicCitation | APPLIED BIOLOGICAL CHEMISTRY, v.63, no.1, pp 1 - 8 | - |
dc.identifier.kciid | ART002660305 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000588723900001 | - |
dc.identifier.scopusid | 2-s2.0-85095759579 | - |
dc.citation.endPage | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | APPLIED BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 63 | - |
dc.type.docType | Article | - |
dc.publisher.location | 싱가폴 | - |
dc.subject.keywordAuthor | Anti-proliferation | - |
dc.subject.keywordAuthor | Brassica vegetables | - |
dc.subject.keywordAuthor | Human disease | - |
dc.subject.keywordAuthor | Isothiocyanate | - |
dc.subject.keywordAuthor | MTT assay | - |
dc.subject.keywordPlus | DETOXIFICATION ENZYMES | - |
dc.subject.keywordPlus | ALLYL ISOTHIOCYANATE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | GENOTOXICITY | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | DEATH | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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