An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy
- Authors
- Sim, Taehoon; Lim, Chaemin; Hoang, Ngoc Ha; Shin, Yuseon; Kim, Jae Chang; Park, June Yong; Her, Jaewon; Lee, Eun Seong; Youn, Yu Seok; Oh, Kyung Taek
- Issue Date
- Sep-2020
- Publisher
- MDPI
- Keywords
- gold nanorod; photothermal therapy; chemotherapy; cancer; pH sensitive polymer; controlled release; nanocluster
- Citation
- PHARMACEUTICS, v.12, no.9, pp 1 - 14
- Pages
- 14
- Journal Title
- PHARMACEUTICS
- Volume
- 12
- Number
- 9
- Start Page
- 1
- End Page
- 14
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53916
- DOI
- 10.3390/pharmaceutics12090839
- ISSN
- 1999-4923
1999-4923
- Abstract
- Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pH(ex)and pH(en)with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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