Alendronate/cRGD-Decorated Ultrafine Hyaluronate Dot Targeting Bone Metastasis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eunsol | - |
dc.contributor.author | Park, Jaeduk | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Kim, Dongin | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.date.accessioned | 2022-01-20T02:41:09Z | - |
dc.date.available | 2022-01-20T02:41:09Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53950 | - |
dc.description.abstract | In this study, we report the hyaluronate dot (dHA) with multiligand targeting ability and a photosensitizing antitumor model drug for treating metastatic bone tumors. Here, the dHA was chemically conjugated with alendronate (ALN, as a specific ligand to bone), cyclic arginine-glycine-aspartic acid (cRGD, as a specific ligand to tumor integrin alpha(v)beta(3)), and photosensitizing chlorin e6 (Ce6, for photodynamic tumor therapy), denoted as (ALN/cRGD)@dHA-Ce6. These dots thus prepared (approximate to 10 nm in diameter) enabled extensive cellular interactions such as hyaluronate (HA)-mediated CD44 receptor binding, ALN-mediated bone targeting, and cRGD-mediated tumor integrin alpha(v)beta(3) binding, thus improving their tumor targeting efficiency, especially for metastasized MDA-MB-231 tumors. As a result, these dots improved the tumor targeting efficiency and tumor cell permeability in a metastatic in vivo tumor model. Indeed, we demonstrated that (ALN/cRGD)@dHA-Ce6 considerably increased photodynamic tumor ablation, the extent of which is superior to that of the tumor ablation of dot systems with single or double ligands. These results indicate that dHA with multiligand can provide an effective treatment strategy for metastatic bone tumors. | - |
dc.format.extent | 17 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Alendronate/cRGD-Decorated Ultrafine Hyaluronate Dot Targeting Bone Metastasis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/biomedicines8110492 | - |
dc.identifier.bibliographicCitation | BIOMEDICINES, v.8, no.11, pp 1 - 17 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000592858100001 | - |
dc.identifier.scopusid | 2-s2.0-85096065779 | - |
dc.citation.endPage | 17 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | BIOMEDICINES | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | hyaluronate dot | - |
dc.subject.keywordAuthor | alendronate | - |
dc.subject.keywordAuthor | cyclic RGD | - |
dc.subject.keywordAuthor | bone metastasis | - |
dc.subject.keywordAuthor | photodynamic tumor therpy | - |
dc.subject.keywordPlus | PHOTODYNAMIC TUMOR-THERAPY | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEM | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | SURFACE FUNCTIONALIZATION | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | INTEGRIN | - |
dc.subject.keywordPlus | ALPHA(V)BETA(3) | - |
dc.subject.keywordPlus | FULLERENE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.