PLGA microsphere construct coated with TGF-beta 3 loaded nanoparticles for neocartilage formation
DC Field | Value | Language |
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dc.contributor.author | Park, Ji Sun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Woo, Dae Gyun | - |
dc.contributor.author | Yang, Han Na | - |
dc.contributor.author | Chung, Hyung-Min | - |
dc.contributor.author | Park, Keun-Hong | - |
dc.date.accessioned | 2022-01-25T01:42:06Z | - |
dc.date.available | 2022-01-25T01:42:06Z | - |
dc.date.issued | 2008-08 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.issn | 1526-4602 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54298 | - |
dc.description.abstract | Polymeric microsphere system has been widely used in tissue-regeneration matrix and drug delivery systems. To apply these biomaterials as novel cell supporting matrix for stem cell delivery, we have devised a novel method for the fabrication of nanostructured 3D scaffolds that growth factor loaded heparin/poly(L-lysine) nanoparticles were physically attached on the positively charged surface of PLGA microspheres precoated with low molecular weight of poly(ethyleneimmine) (PEI) via a layer-by-layer (LbL) system. Based on a previous study, we have prepared poly(lactide-co-glycolide) (PLGA) microspheres harboring heparin/poly(L-lysine) loaded with growth factors. Growth factor loaded heparin/poly(L-lysine) nanoparticles, which were simply produced as polyion complex micelles (PICM) with diameters of 50-150 nm, were fabricated in the first step. Microsphere matrix (size, 20 similar to 80 nm) containing TGF-beta 3 showed a significantly higher number of specific lacunae phenotypes at the end of the 4 week study in vitro culture of mesenchymal stem cells. Thus, growth factor delivery of PLGA microsphere can be used to engineer synthetic extracellular matrix. This PLGA microsphere matrix containing TGF-beta 3 showed promise as coatings for implantable biomedical devices to improve biocompatibility and ensure in vivo performance. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | PLGA microsphere construct coated with TGF-beta 3 loaded nanoparticles for neocartilage formation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/bm800251x | - |
dc.identifier.bibliographicCitation | BIOMACROMOLECULES, v.9, no.8, pp 2162 - 2169 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000258400200011 | - |
dc.citation.endPage | 2169 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2162 | - |
dc.citation.title | BIOMACROMOLECULES | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | HEPARAN-SULFATE PROTEOGLYCANS | - |
dc.subject.keywordPlus | GLYCOLIC ACID) MICROSPHERES | - |
dc.subject.keywordPlus | FIBROBLAST-GROWTH-FACTOR | - |
dc.subject.keywordPlus | ADULT STEM-CELLS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | SPHERES | - |
dc.subject.keywordPlus | BEADS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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