GPx-1-encoded adenoviral vector attenuates dopaminergic impairments induced by methamphetamine in GPx-1 knockout mice through modulation of NF-κB transcription factor
DC Field | Value | Language |
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dc.contributor.author | Sharma, N. | - |
dc.contributor.author | Shin, E.-J. | - |
dc.contributor.author | Pham, D.T. | - |
dc.contributor.author | Sharma, G. | - |
dc.contributor.author | Dang, D.-K. | - |
dc.contributor.author | Duong, C.X. | - |
dc.contributor.author | Kang, S.W. | - |
dc.contributor.author | Nah, S.-Y. | - |
dc.contributor.author | Jang, C.-G. | - |
dc.contributor.author | Lei, X.G. | - |
dc.contributor.author | Nabeshima, T. | - |
dc.contributor.author | Bing, G. | - |
dc.contributor.author | Jeong, J.H. | - |
dc.contributor.author | Kim, H.-C. | - |
dc.date.accessioned | 2022-01-25T02:41:34Z | - |
dc.date.available | 2022-01-25T02:41:34Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.issn | 1873-6351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54316 | - |
dc.description.abstract | We suggested that selenium-dependent glutathione peroxidase (GPx) plays a protective role against methamphetamine (MA)-induced dopaminergic toxicity. We focused on GPx-1, a major selenium-dependent enzyme and constructed a GPx-1 gene-encoded adenoviral vector (Ad-GPx-1) to delineate the role of GPx-1 in MA-induced dopaminergic neurotoxicity. Exposure to Ad-GPx-1 significantly induced GPx activity and GPx-1 protein levels in GPx-1-knockout (GPx-1-KO) mice. MA-induced dopaminergic impairments [i.e., hyperthermia; increased nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) DNA-binding activity; and decreased dopamine levels, TH activity, and behavioral activity] were more pronounced in GPx-1-KO mice than in WT mice. In contrast, exposure to Ad-GPx-1 significantly attenuated MA-induced dopaminergic loss in GPx-1-KO mice. The protective effect exerted by Ad-GPx-1 was comparable to that exerted by pyrrolidine dithiocarbamate (PDTC), an NF-κB inhibitor against MA insult. Consistently, GPx-1 overexpression significantly attenuated MA dopaminergic toxicity in mice. PDTC did not significantly impact the protective effect of GPx-1 overexpression, suggesting that interaction between NF-κB and GPx-1 is critical for dopaminergic protection. Thus, NF-κB is a potential therapeutic target for GPx-1-mediated dopaminergic protective activity. This study for the first time demonstrated that Ad-GPx-1 rescued dopaminergic toxicity in vivo following MA insult. Furthermore, GPx-1-associated therapeutic interventions may be important against dopaminergic toxicity. © 2021 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | GPx-1-encoded adenoviral vector attenuates dopaminergic impairments induced by methamphetamine in GPx-1 knockout mice through modulation of NF-κB transcription factor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fct.2021.112313 | - |
dc.identifier.bibliographicCitation | Food and Chemical Toxicology, v.154 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000677525600002 | - |
dc.identifier.scopusid | 2-s2.0-85107540969 | - |
dc.citation.title | Food and Chemical Toxicology | - |
dc.citation.volume | 154 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | GPx-1 gene-encoded adenoviral vector | - |
dc.subject.keywordAuthor | GPx-1 knockout mice | - |
dc.subject.keywordAuthor | GPx-1 overexpressing transgenic mice | - |
dc.subject.keywordAuthor | Methamphetamine-induced dopaminergic toxicity | - |
dc.subject.keywordAuthor | NF-κB inhibitor | - |
dc.subject.keywordAuthor | Striatum | - |
dc.subject.keywordPlus | adenovirus vector | - |
dc.subject.keywordPlus | dopamine | - |
dc.subject.keywordPlus | glutathione peroxidase 1 | - |
dc.subject.keywordPlus | immunoglobulin enhancer binding protein | - |
dc.subject.keywordPlus | methamphetamine | - |
dc.subject.keywordPlus | pyrrolidine dithiocarbamate | - |
dc.subject.keywordPlus | tyrosine 3 monooxygenase | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | behavior | - |
dc.subject.keywordPlus | central nervous system disease | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | corpus striatum | - |
dc.subject.keywordPlus | DNA binding | - |
dc.subject.keywordPlus | dopaminergic impairment | - |
dc.subject.keywordPlus | dopaminergic toxicity | - |
dc.subject.keywordPlus | drug effect | - |
dc.subject.keywordPlus | enzyme activity | - |
dc.subject.keywordPlus | exposure | - |
dc.subject.keywordPlus | gene function | - |
dc.subject.keywordPlus | gene overexpression | - |
dc.subject.keywordPlus | GPx 1 gene | - |
dc.subject.keywordPlus | hyperthermia | - |
dc.subject.keywordPlus | immunoreactivity | - |
dc.subject.keywordPlus | in vivo study | - |
dc.subject.keywordPlus | intrastriatal drug administration | - |
dc.subject.keywordPlus | knockout mouse | - |
dc.subject.keywordPlus | locomotion | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | modulation | - |
dc.subject.keywordPlus | motor activity | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | neuroprotection | - |
dc.subject.keywordPlus | neurotoxicity | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | protein protein interaction | - |
dc.subject.keywordPlus | rectal temperature | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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