Surface glycan targeting for cancer nano-immunotherapy
- Authors
- Choi, Yonghyun; Kim, Jiwon; Chae, Jayoung; Hong, Joohye; Park, Jongjun; Jeong, Eunseo; Kim, Hayoung; Tanaka, Masayoshi; Okochi, Mina; Choi, Jonghoon
- Issue Date
- Feb-2022
- Publisher
- Elsevier B.V.
- Keywords
- Cancer glycan; Cancer immunotherapy; Glycan targeting; Glycosylation; Nanoparticle
- Citation
- Journal of Controlled Release, v.342, pp 321 - 336
- Pages
- 16
- Journal Title
- Journal of Controlled Release
- Volume
- 342
- Start Page
- 321
- End Page
- 336
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54922
- DOI
- 10.1016/j.jconrel.2022.01.004
- ISSN
- 0168-3659
1873-4995
- Abstract
- Cancer immunotherapy is an emerging therapeutic strategy for cancer treatment. Most of the immunotherapeutics approved by the FDA regulate the innate immune system and associated immune cell activity, with immune check inhibitors in particular having transformed the field of cancer immunotherapy due to their significant clinical potential. However, previously reported immunotherapeutics have exhibited undesirable side effects, including autoimmune toxicity and inflammation. Controlling these deleterious responses and designing therapeutics that can precisely target specific regions are thus crucial to improving the efficacy of cancer immunotherapies. Recent studies have reported that cancer cells employ glycan−immune checkpoint interactions to modulate immune cell activity. Thus, the recognition of cancer glycan moieties such as sialoglycans may improve the anticancer activity of immune cells. In this review, we discuss recent advances in cancer immunotherapies involving glycans and glycan-targeting technologies based on nanomaterial-assisted local delivery systems. © 2022 Elsevier B.V.
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