Preparation of topical bimatoprost with enhanced skin infiltration and in vivo hair regrowth efficacy in androgenic alopecia
DC Field | Value | Language |
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dc.contributor.author | Subedi, Laxman | - |
dc.contributor.author | Pandey, Prashant | - |
dc.contributor.author | Shim, Jung-Hyun | - |
dc.contributor.author | Kim, Ki-Taek | - |
dc.contributor.author | Cho, Seung-Sik | - |
dc.contributor.author | Koo, Kyo-Tan | - |
dc.contributor.author | Kim, Beum Joon | - |
dc.contributor.author | Park, Jin Woo | - |
dc.date.accessioned | 2022-02-10T06:40:17Z | - |
dc.date.available | 2022-02-10T06:40:17Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1071-7544 | - |
dc.identifier.issn | 1521-0464 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54955 | - |
dc.description.abstract | To prepare a topical formulation of bimatoprost (BIM) with high skin permeability, we designed a solvent mixture system composed of ethanol, diethylene glycol monoethyl ether, cyclomethicone, and butylated hydroxyanisole, serving as a volatile solvent, nonvolatile co-solvent, spreading agent, and antioxidant, respectively. The ideal topical BIM formulation (BIM-TF#5) exhibited 4.60-fold higher human skin flux and a 529% increase in dermal drug deposition compared to BIM in ethanol. In addition, compared to the other formulations, BIM-TF#5 maximally activated human dermal papilla cell proliferation at a concentration of 5 mu M BIM, equivalent to 10 mu M minoxidil. Moreover, BIM-TF#5 (0.3% [w/w] BIM) significantly promoted hair regrowth in the androgenic alopecia mouse model and increased the area covered by hair at 10 days by 585% compared to the vehicle-treated mice, indicating that entire telogen area transitioned into the anagen phase. Furthermore, at day 14, the hair weight of mice treated with BIM-TF#5 (5% [w/w] BIM) was 8.45- and 1.30-fold greater than in the 5% (w/w) BIM in ethanol and 5% (w/v) minoxidil treated groups, respectively. In the histological examination, the number and diameter of hair follicles in the deep subcutis were significantly increased in the BIM-TF#5 (0.3 or 5% [w/w] BIM)-treated mice compared to the mice treated with vehicle or 5% (w/w) BIM in ethanol. Thus, our findings suggest that BIM-TF#5 is an effective formulation to treat scalp alopecia, as part of a novel therapeutic approach involving direct prostamide F2 alpha receptor-mediated stimulation of dermal papilla cells within hair follicles. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Preparation of topical bimatoprost with enhanced skin infiltration and in vivo hair regrowth efficacy in androgenic alopecia | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/10717544.2022.2027046 | - |
dc.identifier.bibliographicCitation | DRUG DELIVERY, v.29, no.1, pp 328 - 341 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000743714100001 | - |
dc.identifier.scopusid | 2-s2.0-85123354630 | - |
dc.citation.endPage | 341 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 328 | - |
dc.citation.title | DRUG DELIVERY | - |
dc.citation.volume | 29 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Bimatoprost | - |
dc.subject.keywordAuthor | prostaglandins | - |
dc.subject.keywordAuthor | supersaturated topical delivery system | - |
dc.subject.keywordAuthor | highly skin-permeable | - |
dc.subject.keywordAuthor | alopecia | - |
dc.subject.keywordAuthor | hair growth | - |
dc.subject.keywordAuthor | hair follicles | - |
dc.subject.keywordPlus | GLYCOL MONOETHYL ETHER | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | EYELASH | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PERMEATION | - |
dc.subject.keywordPlus | TRANSCUTOL | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | EYEBROW | - |
dc.subject.keywordPlus | DRUGS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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