Role of arachidonic acid-derived metabolites in the control of pulmonary arterial pressure and hypoxic pulmonary vasoconstriction in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, S. J. | - |
dc.contributor.author | Yoo, Hae Young | - |
dc.contributor.author | Earm, Y. E. | - |
dc.contributor.author | Kim, S. J. | - |
dc.contributor.author | Kim, J. K. | - |
dc.contributor.author | Kim, S. D. | - |
dc.date.accessioned | 2022-02-24T05:41:27Z | - |
dc.date.available | 2022-02-24T05:41:27Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0007-0912 | - |
dc.identifier.issn | 1471-6771 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55293 | - |
dc.description.abstract | Background. The roles of arachidonic acid (AA) metabolites in hypoxia-induced pulmonary vasoconstriction (HPV), a critical physiological mechanism that prevents ventilation/perfusion mismatch, are still incompletely understood. Methods. Pulmonary arterial pressure was measured in ventilated/perfused rat lungs. Isometric tones of rat intralobar pulmonary arteries were also measured, using a myograph. Results. Hypoxia (Po-2, 3%)-induced pulmonary arterial pressure increases (Delta PAP(hypox)) were stable with blood-mixed perfusate, but decayed spontaneously. Delta PAP(hypox) was inhibited by 29%, 16%, and 28% by the thromboxane A(2) (TXA(2)) antagonist SQ-29548, the 5-lipoxygenase inhibitor, MK886, and the leukotriene D-4 antagonist, LY-171883, respectively. The prostacyclin synthase inhibitor tranylcypromine augmented Delta PAP(hypox) by 5%, whereas inhibition of cytochrome P450 did not affect Delta PAP(hypox). Consistently, the TXA(2) analogue U46619 increased Delta PAP(hypox) whereas prostacyclin abolished Delta PAP(hypox). However, leukotriene D-4 had no direct effect on Delta PAP(hypox). In the isolated pulmonary arteries, pretreatment with U46619 was essential to demonstrate hypoxia-induced contraction. Conclusions. The above results suggest that TXA(2) and cysteinyl leukotrienes, other than leukotriene D-4, are endogenous factors that facilitate HPV in rats. The indispensable role of TXA(2)-induced pretone in the HPV of isolated pulmonary arteries indicates that the signal from thromboxane receptors might be a critical component of oxygen sensation mechanisms. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Role of arachidonic acid-derived metabolites in the control of pulmonary arterial pressure and hypoxic pulmonary vasoconstriction in rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/bja/aeq268 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF ANAESTHESIA, v.106, no.1, pp 31 - 37 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000285192900006 | - |
dc.citation.endPage | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.title | BRITISH JOURNAL OF ANAESTHESIA | - |
dc.citation.volume | 106 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | hypoxia | - |
dc.subject.keywordAuthor | lung, blood flow | - |
dc.subject.keywordAuthor | rat | - |
dc.subject.keywordPlus | K+ CHANNELS | - |
dc.subject.keywordPlus | THROMBOXANE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | LEUKOTRIENE-C4 | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.