Inhibition of Hypoxic Pulmonary Vasoconstriction of Rats by Carbon Monoxide
- Authors
- Yoo, Hae Young; Park, Su Jung; Bahk, Jae Hyon; Kim, Sung Joon
- Issue Date
- Oct-2010
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Anoxia; Pulmonary Artery; Carbon Monoxide; Guanylate Cyclase; Oxygen
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.10, pp 1411 - 1417
- Pages
- 7
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 25
- Number
- 10
- Start Page
- 1411
- End Page
- 1417
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55294
- DOI
- 10.3346/jkms.2010.25.10.1411
- ISSN
- 1011-8934
1598-6357
- Abstract
- Hypoxic pulmonary vasoconstriction (HPV), a unique response of pulmonary circulation, is critical to prevent hypoxemia under local hypoventilation. Hypoxic inhibition of K+ channel is known as an important O-2-sensing mechanism in HPV. Carbon monoxide (CO) is suggested as a positive regulator of Ca2+-activated K+ channel (BKCa), a stimulator of guanylate cyclase, and an O-2-mimetic agent in heme moiety-dependent O-2 sensing mechanisms. Here we compared the effects of CO on the HPV (Po-2, 3%) in isolated pulmonary artery (HPVPA) and in blood-perfused/ventilated lungs (HPVlung) of rats. A pretreatment with CO (3%) abolished the HPVPA in a reversible manner. The inhibition of HPVPA was completely reversed by 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ), a guanylate cyclase inhibitor. In contrast, the HPVlung was only partly decreased by CO. Moreover, the partial inhibition of HPVlung by CO was affected neither by the pretreatment with ODQ nor by NO synthase inhibitor (L-NAME). The CO-induced inhibitions of HPVPA and HPVlung were commonly unaffected by tetraethylammonium (TEA, 2 mM), a blocker of BKCa. As a whole, CO inhibits HPVPA via activating guanylate cyclase. The inconsistent effects of ODQ on HPVPA and HPVlung suggest that ODQ may lose its sGC inhibitory action when applied to the blood-containing perfusate.
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Collections - Red Cross College of Nursing > Department of Nursing > 1. Journal Articles
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