Disappearance of Hypoxic Pulmonary Vasoconstriction and O-2-Sensitive Nonselective Cationic Current in Arterial Myocytes of Rats Under Ambient Hypoxia
DC Field | Value | Language |
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dc.contributor.author | Yoo, Hae Young | - |
dc.contributor.author | Kim, Sung Joon | - |
dc.date.accessioned | 2022-02-24T06:40:41Z | - |
dc.date.available | 2022-02-24T06:40:41Z | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55304 | - |
dc.description.abstract | Acute hypoxia induces contraction of pulmonary artery (PA) to protect ventilation/perfusion mismatch in lungs. As for the cellular mechanism of hypoxic pulmonary vasoconstriction (HPV), hypoxic inhibition of voltage-gated K+ channel (Kv) in PA smooth muscle cell (PASMC) has been suggested. In addition, our recent study showed that thromboxane A(2) (TXA(2)) and hypoxia-activated nonselective cation channel (I-NSC) is also essential for HPV. However, it is not well understood whether HPV is maintained in the animals exposed to ambient hypoxia for two days (2d-H). Specifically, the associated eleetrophysiological changes in PASMCs have not been studied. Here we investigate the effects of 2d-H on HPV in isolated ventilated/perfused lungs (V/P lungs) from rats. HPV was almost abolished without structural remodeling of PA in 2d-H rats, and the lost HPV was not recovered by Kv inhibitor, 4-aminopyridine. Patch clamp study showed that the hypoxic inhibition of Kv current in PASMC was similar between 2d-H and control. In contrast, hypoxia and TXA(2)-activated I-NSC was not observed in PASMCs of 2d-H. From above results, it is suggested that the decreased I-NSC might be the primary functional cause of HPV disappearance in the relatively early period (2 d) of hypoxia. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Disappearance of Hypoxic Pulmonary Vasoconstriction and O-2-Sensitive Nonselective Cationic Current in Arterial Myocytes of Rats Under Ambient Hypoxia | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2013.17.5.463 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.17, no.5, pp 463 - 468 | - |
dc.identifier.kciid | ART001816636 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000331593200013 | - |
dc.citation.endPage | 468 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 463 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Chronic hypoxia | - |
dc.subject.keywordAuthor | Hypoxic pulmonary vasoconstriction | - |
dc.subject.keywordAuthor | Nonselective cation channel | - |
dc.subject.keywordAuthor | O-2-sensitive ion channel | - |
dc.subject.keywordAuthor | Pulmonary artery | - |
dc.subject.keywordPlus | K+ CHANNELS | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | LUNGS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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