YES-10 Improves Stress, Tension, and Fatigue by Reducing Cortisol and IL-6 Levels
DC Field | Value | Language |
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dc.contributor.author | Noh, Y.-H. | - |
dc.contributor.author | Hong, J. | - |
dc.contributor.author | Lee, J.-W. | - |
dc.contributor.author | Kim, S.-S. | - |
dc.contributor.author | Kang, I.-J. | - |
dc.contributor.author | Whang, Wan Kyunn | - |
dc.contributor.author | Myung, Soon-Chul | - |
dc.contributor.author | Chung, M.-H. | - |
dc.contributor.author | Won, M.-H. | - |
dc.date.accessioned | 2022-02-28T00:41:01Z | - |
dc.date.available | 2022-02-28T00:41:01Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.issn | 1557-7600 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55350 | - |
dc.description.abstract | The extract of Clematis mandshurica Rupr. (CMR) inhibits the production of proinflammatory mediators from lipopolysaccharide-stimulated peritoneal macrophages and concanavalin A-stimulated splenocytes. Erigeron annuus Pers. (EAP) extract suppresses the production of reactive oxygen species (ROS) from preadipocytes. Furthermore, the mixture of the leaf extracts of CMR and EAP, YES-10®, protected against nerve injuries induced by ischemia/reperfusion, suggesting a ROS-scavenging action. These observations show the anti-inflammatory action of YES-10. Inflammatory cytokines can cause alterations in mental function, including depression, by influencing the neurotransmitter system. Thus, it was hypothesized that YES-10 could improve mental health, such as depression, anxiety, and sense of well-being. Seventy-two subjects were recruited and randomly divided into YES-10 or placebo groups (n = 36 per group). Each group was daily administered two capsules orally, containing 200 mg of YES-10 or placebo, for 4 weeks in a double-blinded manner and tested for levels of depression, anxiety, well-being, and mental fitness using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Psychosocial Well-being Index (PWI), and Mental Fitness Scale (MFS). In addition, the levels of cortisol (a stress hormone), interleukin-6 (IL-6) (an inflammatory cytokine), and 8-hydroxydeoxyguanosine (8-OHdG; a marker of oxidative stress) in the serum were measured. The BDI, BAI, PWI, and MFS scores decreased significantly, and the serum levels of cortisol, IL-6, and 8-OHdG were lowered significantly (P < .05), suggesting that YES-10 has the ability to improve mental health by relieving stress and by decreasing inflammation and oxidative stress. Copyright © 2022 Mary Ann Liebert, Inc. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Mary Ann Liebert Inc. | - |
dc.title | YES-10 Improves Stress, Tension, and Fatigue by Reducing Cortisol and IL-6 Levels | - |
dc.type | Article | - |
dc.identifier.doi | 10.1089/jmf.2021.K.0129 | - |
dc.identifier.bibliographicCitation | Journal of Medicinal Food, v.25, no.2, pp 205 - 212 | - |
dc.identifier.kciid | ART002812067 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000896318300005 | - |
dc.identifier.scopusid | 2-s2.0-85124577979 | - |
dc.citation.endPage | 212 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 205 | - |
dc.citation.title | Journal of Medicinal Food | - |
dc.citation.volume | 25 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | cortisol | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | fatigue | - |
dc.subject.keywordAuthor | stress | - |
dc.subject.keywordAuthor | tension relief | - |
dc.subject.keywordAuthor | YES-10 | - |
dc.subject.keywordPlus | BECK DEPRESSION INVENTORY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ANXIETY-INVENTORY | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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