A split face study on the effect of an anti-acne product containing fermentation products of Enterococcus faecalis CBT SL-5 on skin microbiome modification and acne improvement
- Authors
- Han, Hye Sung; Shin, Sun Hye; Choi, Bo-Yun; Koo, Nayeon.; Lim, Sanghyun.; Son, Dooheon.; Chung, Myung Jun; Park, Kui Young; Sul, Woo Jun
- Issue Date
- May-2022
- Publisher
- The Korean Society for Mocrobiology / The Korean Society of Virology
- Keywords
- acne vulgaris; dysbiosis; Enterococcus faecalis; skin microbiome
- Citation
- Journal of Microbiology, v.60, no.5, pp 488 - 495
- Pages
- 8
- Journal Title
- Journal of Microbiology
- Volume
- 60
- Number
- 5
- Start Page
- 488
- End Page
- 495
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55665
- DOI
- 10.1007/s12275-022-1520-6
- ISSN
- 1225-8873
1976-3794
- Abstract
- Antibiotic-resistant Cutibacterium acnes and dysbiosis of the skin microbiome are of increasing concern in acne treatment. Enterococcus faecalis, a widely used probiotic, has shown benefits for acne treatment by exerting antimicrobial activity against C. acnes. Therefore, this study aimed to investigate the efficacy and safety of an E. faecalis CBT SL-5-extract-containing lotion in patients with mild-to-moderate acne. Twenty patients were enrolled in this randomized, placebo-controlled, split-face comparative study. Patients were treated with E. faecalis lotion on one side of the face and a vehicle lotion on the other side for 4 weeks. The efficacy outcome measures included improvement in the investigators’ assessment of acne severity, patient satisfaction, changes in skin parameters and diversity of the skin microbiome. The investigators’ assessment score was significantly improved on the test side compared to the control side, after 2 weeks (p = 0.009) and 6 weeks (p < 0.0005). However, TEWL and skin hydration were not significantly different between the two groups. The phylogenetic diversity of the skin microbiota decreased over time in the skin samples of test side. In conclusion, E. faecalis CBT SL-5 extract can be a feasible and well-tolerated option for improving acne severity and skin microbiome dysbiosis in mild-to-moderate acne patients. © 2022, The Microbiological Society of Korea.
- Files in This Item
-
- Appears in
Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.