유방암에서 색소원제자리부합화에 의한 HER-2/neu 종양유전자 증폭과 Topoisomerase II-α 의 면역조직화학적 발현
DC Field | Value | Language |
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dc.contributor.author | Lee, Tae Jin | - |
dc.contributor.author | Oh, Hyung Goon | - |
dc.contributor.author | Kwon, Gui Young | - |
dc.contributor.author | Kim, Mi Kyung | - |
dc.contributor.author | Park, Eon Sub | - |
dc.contributor.author | Yoo, Jae Hyung | - |
dc.date.accessioned | 2022-04-06T00:40:25Z | - |
dc.date.available | 2022-04-06T00:40:25Z | - |
dc.date.issued | 2003-02 | - |
dc.identifier.issn | 2383-7837 | - |
dc.identifier.issn | 2383-7845 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55863 | - |
dc.description.abstract | Background : Amplifications of the HER-2/neu oncogene and the Topoisomerase II-α gene are important determiners of the response to chemotherapy in the breast cancer. For detecting HER-2/neu amplification, fluorescent in situ hybridization and immunohistochemistry are currently regarded as standard methods. Chromogenic in situ hybridization (CISH) is investigated as a new modification of in situ hybridization. The purpose of this study is to compare the efficacy of CISH and immunohistochemistry (IHC) in detecting HER-2/neu oncogene amplification and to investigate the prognostic significance of the HER-2/neu oncogene and the Topoisomerase II-α gene in breast cancer. Methods : Using CISH and IHC the amplifications and protein expressions of the HER-2/neu oncogene were studied on paraffin sections of 43 infiltrating duct carcinomas. The expression of the Topoisomerase II-α gene was studied immunohistochemically. Results : Of the 43 infiltrating duct carcinomas, amplifications of the HER-2/neu oncogene by CISH were observed in 8 cases (18.6%), and the HER-2/neu protein was deemed overexpressed by IHC in 9 cases (20.9%). The amplifications of the HER-2/neu oncogene showed a statistically significant correlation with tumor size, histological grade, and the Topoisomerase II-α index. The Topoisomerase II-α index showed a statistically significant correlation with tumor size, lymph node status, stage, histologic grade, and estrogen receptor status. Conclusions : CISH is a useful alternative for determining HER-2/neu amplification, especially for confirming the immunohistochemical staining results. HER-2/neu amplification and the Topoisomerase II-α gene index may be prognostic factors of breast cancer. | - |
dc.format.extent | 9 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한병리학회 | - |
dc.title | 유방암에서 색소원제자리부합화에 의한 HER-2/neu 종양유전자 증폭과 Topoisomerase II-α 의 면역조직화학적 발현 | - |
dc.title.alternative | HER-2/neu Oncogene Amplification by Chromogenic in situ Hybridization and Immunohistochemical Expression of Topoisomerase II-α in the Breast Cancer | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | Journal of Pathology and Translational Medicine, v.37, no.1, pp 26 - 34 | - |
dc.identifier.kciid | ART001188534 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 26 | - |
dc.citation.title | Journal of Pathology and Translational Medicine | - |
dc.citation.volume | 37 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Mammary Neoplasms-In SituHybridization-HER-2/neu-DNA Topoisomerase-type II-α | - |
dc.description.journalRegisteredClass | kci | - |
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