ROLE OF OXYGEN IN THE VITAMIN-K-DEPENDENT CARBOXYLATION REACTION - INCORPORATION OF A 2ND ATOM OF O-18 FROM MOLECULAR OXYGEN-O-18(2) INTO VITAMIN-K OXIDE DURING CARBOXYLASE ACTIVITY
DC Field | Value | Language |
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dc.contributor.author | DOWD, P | - |
dc.contributor.author | HAM, SW | - |
dc.contributor.author | HERSHLINE, R | - |
dc.date.accessioned | 2022-04-06T08:40:11Z | - |
dc.date.available | 2022-04-06T08:40:11Z | - |
dc.date.issued | 1992-09 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.issn | 1520-5126 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55954 | - |
dc.description.abstract | Vitamin K in its hydroquinone form, vitamin KH2, is a cofactor for the enzyme that carboxylates the N-terminal glutamates in six proteins of the blood-clotting cascade. Vitamin KH2 is transformed to vitamin K oxide concurrently with the carboxylation leading to gamma-carboxyglutamate. When vitamin KH2 is treated with O-18(2) in the presence of rat liver microsomes, the product, vitamin K oxide, carries a full atom of O-18 at the epoxide oxygen. This paper reports the partial incorporation of almost 20% of a second atom of O-18 at a carbonyl oxygen of vitamin K oxide. Control reactions demonstrate that exchange with (H2O)-O-18 under the reaction conditions is too slow to account for the additional increment of O-18. It is concluded that the second O-18 arises directly from molecular oxygen and that its incorporation is an integral part of the mechanism of action of vitamin K. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | ROLE OF OXYGEN IN THE VITAMIN-K-DEPENDENT CARBOXYLATION REACTION - INCORPORATION OF A 2ND ATOM OF O-18 FROM MOLECULAR OXYGEN-O-18(2) INTO VITAMIN-K OXIDE DURING CARBOXYLASE ACTIVITY | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/ja00046a001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.114, no.20, pp 7613 - 7617 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | A1992JP51200001 | - |
dc.citation.endPage | 7617 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 7613 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 114 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | MANUMYCIN | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | EPOXIDATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CYANIDE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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