DHEA의 투여 시기가 Dexamethasone 치료 쥐의 체중과 TypeⅠ,Ⅱ 근육무게에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최명애 | - |
dc.contributor.author | 신기수 | - |
dc.contributor.author | 안경주 | - |
dc.contributor.author | 이은주 | - |
dc.date.accessioned | 2022-04-11T05:40:15Z | - |
dc.date.available | 2022-04-11T05:40:15Z | - |
dc.date.issued | 2002-10 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56034 | - |
dc.description.abstract | -Effect of DHEA Administration before, during and after Dexamethasone Treatment on Body Weight and Mass of TypeⅠ,Ⅱ Muscles in Rats Purpose: This study was to determine the effect of DHEA administration before, during, and after dexamethasone treatment on body weight and TypeⅠ,Ⅱ muscle weight of rat receiving dexamethasone treatment. Method: Wistar rats were divided into 6 groups: control(C), dexamethasone(D), DHEA administration for 3days after dexamethasone treatment for 7days(7D+3DH), dexamethasone treatment for 7days after DHEA administration for 3days(3DH+7D), DHEA administration during dexamethasone treatment for 4days after dexamethasone treatment for 3days(3D+4DDH), DHEA administration during dexamethasone treatment for 7days(7DDH). Dexamethasone was injected by subcutaneously daily at a dose of 5mg/kg. DHEA was orally administered daily at a dose of 5mg/kg for 7 days. Soleus(TypeⅠ) muscle, and both plantaris and gastro- cnemius(TypeⅡ) muscles were dissected on the 7th day of experiment. Result: Body weight of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Body weight of 7D+3DH group decreased significantly compared with that of 7D group, 7DDH group, 3DH+7D group and 3D+4DDH group. Muscle weight of both plantaris and gastro- cnemius tended to decrease compared with that of 7D group. Muscle weight of 7DDH group, 3D+4DDH group and 3DH+7D group increased significantly compared with that of 7D+3DH group. Muscle weight of gastrocnemius of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Conclusion: Based on these results, it can be suggested that DHEA administration before and during dexamethasone treatment can increase both body weight and mass of atrophied TypeⅡ muscle induced by dexa- methasone treatment. | - |
dc.format.extent | 8 | - |
dc.publisher | 한국간호과학회 | - |
dc.title | DHEA의 투여 시기가 Dexamethasone 치료 쥐의 체중과 TypeⅠ,Ⅱ 근육무게에 미치는 영향 | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | Journal of Korean Academy of Nursing, v.32, no.5, pp 727 - 734 | - |
dc.identifier.kciid | ART000900942 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 734 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 727 | - |
dc.citation.title | Journal of Korean Academy of Nursing | - |
dc.citation.volume | 32 | - |
dc.subject.keywordAuthor | DHEA | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | body weight | - |
dc.subject.keywordAuthor | muscle mass | - |
dc.subject.keywordAuthor | TypeⅠ | - |
dc.subject.keywordAuthor | Ⅱ muscle | - |
dc.subject.keywordAuthor | DHEA | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | body weight | - |
dc.subject.keywordAuthor | muscle mass | - |
dc.subject.keywordAuthor | TypeⅠ | - |
dc.subject.keywordAuthor | Ⅱ muscle | - |
dc.description.journalRegisteredClass | kci | - |
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