Effects of collagen sponge dressing delivering epidermal growth factor on collagen fibril regeneration and biomechanical wound strength

Abstract

The effects of epidermal growth factor (EGF) loaded in collagen sponge matrix on fibroblast proliferation rate and collagen fibril organization of the dermis in deep 2nd degree burn rabbit ear model was investigated. The study was investigated to better define the relationship between dermal regeneration and biomechanical properties of the wound. It was found that collagen fibril networks were largely responsible for the final functional properties of the wound. The results show that extraneous supplies of collagen and EGF on deep 2nd degree burn enhanced collagen fibril networks and wound strength.