Emerging roles of inositol pyrophosphates as key modulators of fungal pathogenicity
DC Field | Value | Language |
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dc.contributor.author | Kang, Hyun Ah | - |
dc.date.accessioned | 2022-04-13T00:40:08Z | - |
dc.date.available | 2022-04-13T00:40:08Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 2150-5594 | - |
dc.identifier.issn | 2150-5608 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56336 | - |
dc.description.abstract | Inositol pyrophosphates (PP-IPs) are energy-rich small molecules that are omnipresent in eukaryotic cells, from yeast to mammals, playing central roles in overall cellular homeostasis as a diverse and multifaceted class of intracellular messengers. Recent studies of the metabolic pathways and physiological roles of PP-IPs in the human pathogenic fungus Cryptococcus neoformans have revealed that the PP-IP5 (IP7) is a key metabolite essential for fungal metabolic adaptation to the host environment, immune recognition, and pathogenicity. This suggests the PP-IP biosynthesis pathway, comprising phospholipase C1 (Plc1) and a series of sequentially acting inositol polyphosphate kinases (IPKs), as a new virulence-related signaling pathway in C. neoformans. Given that fungal species have a reduced array of the kinases required for the synthesis of PP-IPs and that the homology between human and fungal IPKs is restricted to a few catalytically important residues, identification of IPK inhibitors specifically targeting the kinases of pathogenic fungi has emerged as a desirable and achievable strategy for antifungal drug development. | - |
dc.format.extent | 3 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.title | Emerging roles of inositol pyrophosphates as key modulators of fungal pathogenicity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/21505594.2017.1421832 | - |
dc.identifier.bibliographicCitation | VIRULENCE, v.9, no.1, pp 563 - 565 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000426967300021 | - |
dc.identifier.scopusid | 2-s2.0-85046303552 | - |
dc.citation.endPage | 565 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 563 | - |
dc.citation.title | VIRULENCE | - |
dc.citation.volume | 9 | - |
dc.type.docType | Editorial Material | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Cryptococcus neoformans | - |
dc.subject.keywordAuthor | Fungal infection | - |
dc.subject.keywordAuthor | Inositol pyrophosphates | - |
dc.subject.keywordAuthor | Pathogenicity | - |
dc.subject.keywordPlus | CRYPTOCOCCAL MENINGITIS | - |
dc.subject.keywordPlus | GLOBAL BURDEN | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | STRESS | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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