Thermochemical Investigation of the Oxygenation of Vitamin K
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Flowers, Robert A. | - |
dc.contributor.author | Naganathan, Sriram | - |
dc.contributor.author | Dowd, Paul | - |
dc.contributor.author | Arnett, Edward M. | - |
dc.contributor.author | Ham, Seung Wook | - |
dc.date.accessioned | 2022-04-13T01:40:05Z | - |
dc.date.available | 2022-04-13T01:40:05Z | - |
dc.date.issued | 1993-10 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.issn | 1520-5126 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56355 | - |
dc.description.abstract | Discovery of a new oxygenation reaction of naphthohydroquinone anions makes possible a determination of the heat of reaction (DELTAH(ox)) of oxygen with the potassium salt derived from deprotonation of the hydroquinone form of vitamin K. From that value (-33.52 +/- 0.60 kcal/mol), the heat of deprotonation of vitamin KH2 (-30.03 +/- 1.20 kcal/mol), and the heat of deprotonation of water (-6.05 +/- 0.3 kcal/mol), the enthalpy change for converting vitamin KH2 to vitamin K oxide is established to be -57.5 kcal/mol, in reasonable agreement with our previous estimate of -62.4 kcal/mol for the oxygenation of the parent naphthohydroquinone. Indeed, in similar fashion the heat of oxygenation of the parent naphthohydroquinone was determined to be -58.47 kcal/mol, and this permits the assignment of a heat of formation to naphthoquinone epoxide of DELTAH(f)degrees = -47.6 kcal/mol. Heats of oxygenation and deprotonation of a variety of related phenols and naphthols provide perspective on cation and substitution effects. These data provide strong support for the base strength amplification mechanism for the biological action of vitamin K proposed by two of us (P.D. and S.W.H.). | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Thermochemical Investigation of the Oxygenation of Vitamin K | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/ja00074a006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.115, no.21, pp 9409 - 9416 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | A1993MD06900006 | - |
dc.citation.endPage | 9416 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 9409 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 115 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | DEPENDENT CARBOXYLASE | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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