Novel bidentate β-glutamic acid-based bone-targeting agents for in vivo bone imaging
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, J.S. | - |
dc.contributor.author | Lim, Y.G. | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.date.accessioned | 2022-04-22T07:40:07Z | - |
dc.date.available | 2022-04-22T07:40:07Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56664 | - |
dc.description.abstract | Due to the unique calcium mineral composition of bone, bone-targeting agents that coordinate with calcium or recognize hydroxyapatite (HAp) have been used to deliver drugs or as imaging agents for the therapy and diagnosis of bone-related diseases. To date, various bisphosphonates or acidic oligopeptide-based bone-targeting agents have been explored. However, bisphosphonates can induce osteonecrosis, and acidic oligopeptide-based molecules have not yet been validated in in vivo bone imaging. In this study, we newly designed β-glutamic acid (βE)-based bone-targeting agents by conjugating mono-βE or tri-βE with polyethylene glycol (PEG) labeled with Cy7 dye (termed as βE-PEG-Cy7 or βEEE-PEG-Cy7). In vitro and in vivo studies showed that βEEE-PEG-Cy7 binds more strongly to calcium-containing particles and HAp than βE-PEG-Cy7, leading to a clearer visualization of bone tissues and knee joints. Compared to alendronate conjugated-PEG-Cy7 (ALN-PEG-Cy7) as a positive control, βEEE-PEG-Cy7 has lower binding affinity to both HAp and bone tissues, whereas it showed less cytotoxicity toward osteoblastic-like cells. Although βEEE-PEG-Cy7 has a lower performance of binding affinity to HAp and in vivo bone tissues, we believe that βEEE-PEG-Cy7 with less toxicity can be used as a bone-targeting agent for in vivo bone tissue imaging. © 2022 The Korean Society of Industrial and Engineering Chemistry | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Industrial Engineering Chemistry | - |
dc.title | Novel bidentate β-glutamic acid-based bone-targeting agents for in vivo bone imaging | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jiec.2022.03.021 | - |
dc.identifier.bibliographicCitation | Journal of Industrial and Engineering Chemistry, v.110, pp 471 - 478 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000883407400001 | - |
dc.identifier.scopusid | 2-s2.0-85127895660 | - |
dc.citation.endPage | 478 | - |
dc.citation.startPage | 471 | - |
dc.citation.title | Journal of Industrial and Engineering Chemistry | - |
dc.citation.volume | 110 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Bone targeting imaging | - |
dc.subject.keywordAuthor | Fluorescence imaging | - |
dc.subject.keywordAuthor | Hydroxyapatite | - |
dc.subject.keywordAuthor | β-Glutamic acid | - |
dc.subject.keywordPlus | SELECTIVE DRUG-DELIVERY | - |
dc.subject.keywordPlus | POLYETHYLENE-GLYCOL | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | BISPHOSPHONATE | - |
dc.subject.keywordPlus | CALCIFICATION | - |
dc.subject.keywordPlus | FLUOROPHORES | - |
dc.subject.keywordPlus | OLIGOPEPTIDE | - |
dc.subject.keywordPlus | COMPLEXATION | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.