누드 마우스에 이종이식된 인형 구강편평세포암에서 선택적 COX-2 억제제가 종양의 성장에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이규석 | - |
dc.contributor.author | 백상흠 | - |
dc.contributor.author | 양훈식 | - |
dc.contributor.author | 김춘길 | - |
dc.contributor.author | 임도형 | - |
dc.contributor.author | 문석균 | - |
dc.contributor.author | 백광진 | - |
dc.contributor.author | 이태진 | - |
dc.date.accessioned | 2022-04-27T01:40:30Z | - |
dc.date.available | 2022-04-27T01:40:30Z | - |
dc.date.issued | 2003-02 | - |
dc.identifier.issn | 2092-5859 | - |
dc.identifier.issn | 2092-6529 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56812 | - |
dc.description.abstract | Background and Objectives:Recent studies have demonstrated overexpression of cycloxygenase-2 (COX-2) in various can-cers including head and neck cancers. COX-2, an inducible enzyme which catalyzes the formation of prostaglandins from arachidonic acid, is expressed in some cancers. We investigated the anti-tumor effect of selective COX-2 inhibitor, Meloxicam, on Materials and Method:We inoculated the oral cavity cancer cell (KB cell) line subcutaneously into 30 athymic mice which were divided into 3 groups 1 wek after inoculation. One group received no treatment whereas two other groups received selective COX-2 inhibitor, Meloxicam, 10mg/kg and 40mg/kg three times wekly for 3 weks. We studied mean tumor volume, apoptotic index (TUNEL) and proliferative index (Ki 67) in the control and treated groups. Results:(p<0.01), and suppressed the xenografted tumor growth with significant diference (p<0.05) in the Meloxicam treated group. Al tumor expresed COX-2. Conclusion:This result suggested that the selective COX-2 inhibitors suppresed the growth of human oral cavity squamous carcinoma and a further study will be needed for determination of the pharmacologic pathway and eficacy of selective COX-2 inhibitor for head and neck cancers. (Korean J Otolaryngol 2003 ;46 :313-7) | - |
dc.format.extent | 5 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한이비인후과학회 | - |
dc.title | 누드 마우스에 이종이식된 인형 구강편평세포암에서 선택적 COX-2 억제제가 종양의 성장에 미치는 영향 | - |
dc.title.alternative | The Effect of Selective COX-2 Inhibitor on Tumor Growth of Xenografted Human Oral Cavity Cancer in Nude Mice | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한이비인후과학회지 두경부외과학, v.46, no.4, pp 313 - 317 | - |
dc.identifier.kciid | ART000855435 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 317 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 313 | - |
dc.citation.title | 대한이비인후과학회지 두경부외과학 | - |
dc.citation.volume | 46 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Cyclooxygenase inhibitors | - |
dc.subject.keywordAuthor | Squamous cell carcinoma | - |
dc.subject.keywordAuthor | COX억제제 | - |
dc.subject.keywordAuthor | 편평상피세포암 | - |
dc.subject.keywordAuthor | 세포연사 | - |
dc.description.journalRegisteredClass | kci | - |
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