Csm4, in Collaboration with Ndj1, Mediates Telomere-Led Chromosome Dynamics and Recombination during Yeast Meiosis
DC Field | Value | Language |
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dc.contributor.author | Wanat, Jennifer J. | - |
dc.contributor.author | Kim, Keun Pil | - |
dc.contributor.author | Koszul, Romain | - |
dc.contributor.author | Zanders, Sarah | - |
dc.contributor.author | Weiner, Beth | - |
dc.contributor.author | Kleckner, Nancy | - |
dc.contributor.author | Alani, Eric | - |
dc.date.accessioned | 2022-05-09T08:40:20Z | - |
dc.date.available | 2022-05-09T08:40:20Z | - |
dc.date.issued | 2008-09 | - |
dc.identifier.issn | 1553-7390 | - |
dc.identifier.issn | 1553-7404 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57446 | - |
dc.description.abstract | Chromosome movements are a general feature of mid-prophase of meiosis. In budding yeast, meiotic chromosomes exhibit dynamic movements, led by nuclear envelope (NE)-associated telomeres, throughout the zygotene and pachytene stages. Zygotene motion underlies the global tendency for colocalization of NE-associated chromosome ends in a "bouquet.'' In this study, we identify Csm4 as a new molecular participant in these processes and show that, unlike the two previously identified components, Ndj1 and Mps3, Csm4 is not required for meiosis-specific telomere/NE association. Instead, it acts to couple telomere/ NE ensembles to a force generation mechanism. Mutants lacking Csm4 and/or Ndj1 display the following closely related phenotypes: (i) elevated crossover (CO) frequencies and decreased CO interference without abrogation of normal pathways; (ii) delayed progression of recombination, and recombination-coupled chromosome morphogenesis, with resulting delays in the MI division; and (iii) nondisjunction of homologs at the MI division for some reason other than absence of (the obligatory) CO(s). The recombination effects are discussed in the context of a model where the underlying defect is chromosome movement, the absence of which results in persistence of inappropriate chromosome relationships that, in turn, results in the observed mutant phenotypes. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Csm4, in Collaboration with Ndj1, Mediates Telomere-Led Chromosome Dynamics and Recombination during Yeast Meiosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pgen.1000188 | - |
dc.identifier.bibliographicCitation | PLOS GENETICS, v.4, no.9 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000260411200003 | - |
dc.identifier.scopusid | 2-s2.0-52949149726 | - |
dc.citation.number | 9 | - |
dc.citation.title | PLOS GENETICS | - |
dc.citation.volume | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | SYNAPTONEMAL COMPLEX-FORMATION | - |
dc.subject.keywordPlus | OSCILLATORY NUCLEAR-MOVEMENT | - |
dc.subject.keywordPlus | SISTER-CHROMATID COHESION | - |
dc.subject.keywordPlus | MEIOTIC DNA-REPLICATION | - |
dc.subject.keywordPlus | SPINDLE POLE BODY | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | CROSSING-OVER | - |
dc.subject.keywordPlus | BUDDING YEAST | - |
dc.subject.keywordPlus | CROSSOVER INTERFERENCE | - |
dc.subject.keywordPlus | FISSION YEAST | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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