Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Wei | - |
dc.contributor.author | Kim, Alexander Y. | - |
dc.contributor.author | Ky, Sokun | - |
dc.contributor.author | Rakowski, Carrie | - |
dc.contributor.author | Seo, Sang-Beom | - |
dc.contributor.author | Chakravarti, Debabrata | - |
dc.contributor.author | Atchison, Michael | - |
dc.contributor.author | Blobel, Gerd A. | - |
dc.date.accessioned | 2022-05-11T00:40:09Z | - |
dc.date.available | 2022-05-11T00:40:09Z | - |
dc.date.issued | 2002-06 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.issn | 1098-5549 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57466 | - |
dc.description.abstract | Aberrant expression of PU.1 inhibits erythroid cell differentiation and contributes to the formation of murine erythroleukemias (MEL). The molecular mechanism by which this occurs is poorly understood. Here we show that PU.1 specifically and efficiently inhibits CBP-mediated acetylation of several nuclear proteins, including the hematopoietic transcription factors GATA-1, NF-E2, and erythroid Kruppel-like factor. In addition, PU.1 blocks acetylation of histones and interferes with acetylation-dependent transcriptional events. CBP acetyltransferase activity increases during MEL cell differentiation as PU.1 levels decline and is inhibited by sustained PU.1 expression. Finally, PU.1 inhibits the differentiation-associated increase in histone acetylation at an erythroid-specific gene locus in vivo. Together, these findings suggest that aberrant expression of PU.1 and possibly other members of the Ets family of oncoproteins subverts normal cellular differentiation in part by inhibiting the acetylation of critical nuclear factors involved in balancing cellular proliferation and maturation. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.title | Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1128/MCB.22.11.3729-3743.2002 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.22, no.11, pp 3729 - 3743 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000175557600016 | - |
dc.identifier.scopusid | 2-s2.0-0036094806 | - |
dc.citation.endPage | 3743 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3729 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | CREB-BINDING-PROTEIN | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR GATA-1 | - |
dc.subject.keywordPlus | HISTONE ACETYLATION | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ACETYLTRANSFERASE ACTIVITY | - |
dc.subject.keywordPlus | PU.1 TRANSCRIPTION | - |
dc.subject.keywordPlus | CROSS-TALK | - |
dc.subject.keywordPlus | P300 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.