Changes in Lp(a) lipoprotein and lipid levels after cessation of female sex hormone production and estrogen replacement therapy
DC Field | Value | Language |
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dc.contributor.author | Kim, C.J. | - |
dc.contributor.author | Ryu, W.S. | - |
dc.contributor.author | Kwak, J.W. | - |
dc.contributor.author | Park, C.T. | - |
dc.contributor.author | Ryoo, U.H. | - |
dc.date.accessioned | 2022-05-11T02:40:45Z | - |
dc.date.available | 2022-05-11T02:40:45Z | - |
dc.date.issued | 1996-03 | - |
dc.identifier.issn | 0003-9926 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57536 | - |
dc.description.abstract | Objective: To investigate the serial changes in Lp(a) lipoprotein levels with the loss of female sex hormones by surgical menopause and with estrogen replacement therapy in the same women. Patients and Methods: Forty-four premenopausal women who underwent a transabdominal hysterectomy (TAH) because of benign gynecological disorders were divided into two groups: women who underwent a TAH and unilateral salpingo-oophorectomy (n=31) and women who underwent a TAH and bilateral salpingo-oophorectomy (n= 13). In the group of women who underwent a TAH and bilateral salpingo-oophorectomy, 0.625 mg of conjugated equine estrogen was given daily 2 months after the operation. The levels of Lp(a) lipoprotein and lipids were measured before and at 2 and 4 months after the operation. Results: In the group of women who underwent a TAH and bilateral salpingo-oophorectomy, the mean (±SD) concentration of Lp(a) lipoprotein was increased by 24.5% from 0.48±0.47 mmol/L (18.4±18.3 mg/dL) to 0.59±0.54 mmol/L (22.9±21.0 mg/dL) after 2 months(P<.05), and it was reduced by 30.6% to 0.41±0.51 mmol/L (15.9±20.1 mg/dL) (P<.005) with therapy with conjugated equine estrogen (Premarin). The Lp(a) lipoprotein levels were not changed in the group of women who underwent a TAH and unilateral salpingo-oophorectomy. In the group of women who underwent a TAH and bilateral salpingo-oophorectomy, the high-density lipoprotein cholesterol level showed a trend of increase after 2 months from 1.45±0.48 mmol/L (56.1±18.5 mg/dL) to 1.58±0.39 mmol/L (61.2±15.1 mg/dL) without statistical significance, and it revealed a significant elevation to 1.76±0.43 mmol/L (68.2±16.8 mg/dL) with therapy with conjugated equine estrogen (Premarin) compared with that of the basal level (P<.05). Conclusions: The Lp(a) lipoprotein levels appear to be closely associated with female sex hormones. This association might play a pivotal role in postmenopausal increases of atherosclerotic diseases and cardioprotective effect of estrogen in postmenopausal women. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Changes in Lp(a) lipoprotein and lipid levels after cessation of female sex hormone production and estrogen replacement therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1001/archinte.156.5.500 | - |
dc.identifier.bibliographicCitation | Archives of Internal Medicine, v.156, no.5, pp 500 - 504 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-0005902428 | - |
dc.citation.endPage | 504 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 500 | - |
dc.citation.title | Archives of Internal Medicine | - |
dc.citation.volume | 156 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.description.journalRegisteredClass | scopus | - |
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