Drug nano- and microparticles processed into solid dosage forms: Physical properties
- Authors
- Lee, Jonghwi
- Issue Date
- Oct-2003
- Publisher
- JOHN WILEY & SONS INC
- Keywords
- nanoparticles; particle size; insolubility; solid dosage; suspension
- Citation
- JOURNAL OF PHARMACEUTICAL SCIENCES, v.92, no.10, pp 2057 - 2068
- Pages
- 12
- Journal Title
- JOURNAL OF PHARMACEUTICAL SCIENCES
- Volume
- 92
- Number
- 10
- Start Page
- 2057
- End Page
- 2068
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57556
- DOI
- 10.1002/jps.10471
- ISSN
- 0022-3549
1520-6017
- Abstract
- The use of nanoparticles of relatively insoluble drugs has enormously widened the window of achievable pharmacokinetic performance. For the successful development of this technology, it is essential to understand the characteristics of nanoparticles. In this study, the processability and solid dosage performance of nanoparticulates are compared with those of microparticulates. Nanoparticle suspensions are first prepared by wet comminution in the presence of stabilizers. Spray drying converts them into dried particles from which compacts are prepared. Nanoparticles easily form aggregates during spray drying. These aggregates can be slowly redispersed into nanoparticles in water. Compacts show differences in their internal structure and micromechanical deformations, according to the size of their primary particles. Stress to break and indentation hardness are found to be only slightly higher in nanoparticulate systems. (C) 2003 Wiley-Liss, Inc.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.