NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bera, Tapan K | - |
dc.contributor.author | Das, Sudipto | - |
dc.contributor.author | Maeda, Hiroshi | - |
dc.contributor.author | Beers, Richard | - |
dc.contributor.author | Wolfgang, Curt D. | - |
dc.contributor.author | Kumar, Vasantha | - |
dc.contributor.author | Hahn, Yoonsoo | - |
dc.contributor.author | Lee, Byungkook | - |
dc.contributor.author | Pastan, Ira | - |
dc.date.accessioned | 2022-05-13T01:40:18Z | - |
dc.date.available | 2022-05-13T01:40:18Z | - |
dc.date.issued | 2004-03 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.issn | 1091-6490 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57587 | - |
dc.description.abstract | We identified a gene (NGEP) that is expressed only in prostate cancer and normal prostate. The two NGEP transcripts are 0.9 kb and 3.5 kb in size and are generated by a differential splicing event. The short variant (NGEP-S) is derived from four exons and encodes a 20-kDa intracellular protein. The long form (NGEP-L) is derived from 18 exons and encodes a 95-kDa protein that is predicted to contain seven-membrane-spanning regions. In situ hybridization shows that NGEP mRNA is localized in epithelia[ cells of normal prostate and prostate cancers. Immunocytochemical analysis of cells transfected with NGEP cDNAs containing a Myc epitope tag at the carboxyl terminus shows that the protein encoded by the short transcript is localized in the cytoplasm, whereas the protein encoded by the long transcript is present on the plasma membrane. Because of its selective expression in prostate cancer and its presence on the cell surface, NGEP-L is a promising target for the antibody-based therapies of prostate cancer. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.0308746101 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.101, no.9, pp 3059 - 3064 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000220065300074 | - |
dc.identifier.scopusid | 2-s2.0-1542327681 | - |
dc.citation.endPage | 3064 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 3059 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 101 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | HOMOLOGY | - |
dc.subject.keywordPlus | DATABASE | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | TESTIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.