Fracture Preventing Effects of Maxmarvil® Tablets (Alendronate 5 mg + Calcitriol 0.5 μg) in Patients with Osteoporosis
DC Field | Value | Language |
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dc.contributor.author | 유준일 | - |
dc.contributor.author | 하용찬 | - |
dc.contributor.author | 원예연 | - |
dc.contributor.author | 양규현 | - |
dc.contributor.author | 김상범 | - |
dc.contributor.author | 유주형 | - |
dc.contributor.author | 김동수 | - |
dc.date.available | 2019-03-08T10:57:48Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2287-6375 | - |
dc.identifier.issn | 2287-7029 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/5760 | - |
dc.description.abstract | Background: The purpose of this prospective, open-label, observational study was to assess the fracture preventing effect of Maxmarvil® tablets (alendronate 5 mg + calcitriol 0.5 μg) in patients with osteoporosis and to evaluate the change in bone mineral density (BMD) at the minimum 1-year follow-up. Methods: In this multicenter observational study, 691 patients with osteoporosis (aged 50 years or older) were treated with alendronate 5 mg + calcitriol 0.5 μg/day during their normal course of care. Patients were assessed at baseline and at 6 and 12 months. Baseline characteristics (including age, gender, concomitant disease, and baseline fractures) were evaluated. Results: From among the 848 participants, 149 individuals were lost to follow-up at the time of the study and 8 people had died. The 691 participants (54 men and 637 women) finished the follow-up study and completed the questionnaire. The mean age of the participants was 71.5 years (range, 50-92 years; mean age, 72.3 years for men and 71.4 years for women). Osteoporotic fracture occurred in 19 patients (2.7%). BMD of the lumbar spine and hip was improved by 5% and 1.5% at the latest follow-up. At the latest follow-up, 24 patients (3.5%) complained of drug-related complications such as dyspepsia, constipation, and nausea. Conclusions: This prospective observational study demonstrated that alendronate 5 mg + calcitriol 0.5 μg/day had a preventive effect on osteoporotic fracture and it increased the BMD of the lumbar spine by 5% at the latest follow-up. | - |
dc.format.extent | 6 | - |
dc.publisher | 대한골대사학회 | - |
dc.title | Fracture Preventing Effects of Maxmarvil® Tablets (Alendronate 5 mg + Calcitriol 0.5 μg) in Patients with Osteoporosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.11005/jbm.2017.24.2.91 | - |
dc.identifier.bibliographicCitation | 대한골대사학회지, v.24, no.2, pp 91 - 96 | - |
dc.identifier.kciid | ART002228977 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 96 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 91 | - |
dc.citation.title | 대한골대사학회지 | - |
dc.citation.volume | 24 | - |
dc.subject.keywordAuthor | Alendronate | - |
dc.subject.keywordAuthor | Bone density | - |
dc.subject.keywordAuthor | Calcitriol | - |
dc.subject.keywordAuthor | Osteoporosis | - |
dc.subject.keywordAuthor | Osteoporotic fractures | - |
dc.description.journalRegisteredClass | kci | - |
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