Anti-inflammatory effects of two lupane-type triterpenes from leaves of Acanthopanax gracilistylus on LPS-induced RAW264.7 macrophages
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Luo, J. | - |
dc.contributor.author | Li, X.-J. | - |
dc.contributor.author | Lee, G.-H. | - |
dc.contributor.author | Huang, J.-J. | - |
dc.contributor.author | Whang, W.-K. | - |
dc.contributor.author | Zhang, X. | - |
dc.contributor.author | Yook, C.-S. | - |
dc.contributor.author | Liu, X.-Q. | - |
dc.date.accessioned | 2022-05-16T08:40:11Z | - |
dc.date.available | 2022-05-16T08:40:11Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 0101-2061 | - |
dc.identifier.issn | 1678-457X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57707 | - |
dc.description.abstract | Acanthopanax gracilistylus W.W.Smith (AGS) is an traditional Chinese medicine and its leaves that have rich biological activities has been long used as a fresh vegetable in Chinese folk. There are two lupane-type triterpenoids, 3α,11α-dihydroxy-23-oxo-lup-20(29)-en-28-oic acid (1) and 3α,11α,23-trihydroxy-lup-20(29)-en-28-oic acid (2), were isolated as the active constituents from leaves of AGS. However, the anti-inflammatory effects and potential mechanisms of 1 and 2 on LPS-induced RAW264.7 Macrophages have not been evaluated. In this study, the results shown that compounds 1 and 2 reduced the levels of early proinflammatory cytokines TNF-α, IL-1β, the secretion of late pro-inflammatory cytokine HMGB1, as well as the activation of transcription factor NF-κB in RAW 264.7 macrophages induced by LPS. In conclusion, two lupane-type triterpenes (1 and 2) have anti-inflammatory activities in LPS-induced RAW264.7 cells through inhibiting expression of proinflammatory cytokines and NF‐κB activation and could be potentially used in treatment of inflammatory-related diseases in the future. © 2022, Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA | - |
dc.title | Anti-inflammatory effects of two lupane-type triterpenes from leaves of Acanthopanax gracilistylus on LPS-induced RAW264.7 macrophages | - |
dc.type | Article | - |
dc.identifier.doi | 10.1590/fst.89721 | - |
dc.identifier.bibliographicCitation | Food Science and Technology (Brazil), v.42 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000826093700114 | - |
dc.identifier.scopusid | 2-s2.0-85126738448 | - |
dc.citation.title | Food Science and Technology (Brazil) | - |
dc.citation.volume | 42 | - |
dc.type.docType | Article | - |
dc.publisher.location | 브라질 | - |
dc.subject.keywordAuthor | Acanthopanax gracilistylus W.W. Smith | - |
dc.subject.keywordAuthor | HMGB1 | - |
dc.subject.keywordAuthor | Lupane-type triterpenes | - |
dc.subject.keywordAuthor | NF-κB | - |
dc.subject.keywordAuthor | Proinflammatory cytokines | - |
dc.subject.keywordAuthor | RAW 264.7 macrophages | - |
dc.subject.keywordPlus | GROUP BOX 1 | - |
dc.subject.keywordPlus | MOBILITY GROUP BOX-1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | INDUCED TNF-ALPHA | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | HMGB1 | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | IL-1-BETA | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.