Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jiang, Hongmei | - |
dc.contributor.author | Rhee, Sangmyung | - |
dc.contributor.author | Ho, Chin-Han | - |
dc.contributor.author | Grinnell, Frederick | - |
dc.date.accessioned | 2022-05-16T08:40:14Z | - |
dc.date.available | 2022-05-16T08:40:14Z | - |
dc.date.issued | 2008-07 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.issn | 1530-6860 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57710 | - |
dc.description.abstract | Understanding growth factor function during wound repair is necessary for the development of therapeutic interventions to improve healing outcomes. In the current study, we compare the effects of serum and purified growth factors on human fibroblast function in three different collagen matrix models: cell migration in nested matrices, floating matrix contraction, and stressed-released matrix contraction. The results of these studies indicate that platelet-derived growth factor (PDGF) is unique in its capacity to promote cell migration. Serum, lysophosphatidic acid, sphingosine-1-phophate (S1P), and endothelin-1 promote stressed-released matrix contraction but not cell migration. In addition, we found that S1P inhibits fibroblast migration and treatment of serum to remove lipid growth factors or treatment of cells to interfere with S1P(2) receptor function increases serum promigratory activity. Our findings suggest that different sets of growth factors generate promigratory and procontractile tissue environments for fibroblasts and that the balance between PDGF and S1P is a key determinant of fibroblast promigratory activity. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.title | Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices | - |
dc.type | Article | - |
dc.identifier.doi | 10.1096/fj.07-097014 | - |
dc.identifier.bibliographicCitation | FASEB JOURNAL, v.22, no.7, pp 2151 - 2160 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000257292500007 | - |
dc.identifier.scopusid | 2-s2.0-46749123441 | - |
dc.citation.endPage | 2160 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2151 | - |
dc.citation.title | FASEB JOURNAL | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | cell migration | - |
dc.subject.keywordAuthor | cell contraction | - |
dc.subject.keywordAuthor | platelet-derived growth factor | - |
dc.subject.keywordAuthor | lysophosphatidic acid | - |
dc.subject.keywordAuthor | sphingosine-1-phosphate | - |
dc.subject.keywordAuthor | wound repair | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTOR | - |
dc.subject.keywordPlus | LYSOPHOSPHATIDIC ACID | - |
dc.subject.keywordPlus | SPHINGOSINE 1-PHOSPHATE | - |
dc.subject.keywordPlus | GEL CONTRACTION | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | WOUND CONTRACTION | - |
dc.subject.keywordPlus | TISSUE-REPAIR | - |
dc.subject.keywordPlus | I COLLAGEN | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.