High-resolution crystal structure of Acinetobacter baumannii thioredoxin 1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Y.J. | - |
dc.contributor.author | Park, H.H. | - |
dc.date.accessioned | 2022-05-16T09:40:10Z | - |
dc.date.available | 2022-05-16T09:40:10Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57724 | - |
dc.description.abstract | Thioredoxin (Trx) is a central component of the redox control system that maintains the redox homeostasis critical for organism survival. Owing to its central role in survival, Trx is a prospective target for novel antimicrobial agents. Herein, we report a 1.45 Å high-resolution structure of Trx1 of Acinetobacter baumannii (abTrx1), an antibiotic-resistant pathogenic superbug. Although abTrx1 exhibited the canonical Trx fold, which consists of a four-stranded β-sheet surrounded by four α-helices, structural differences were detected in the loop forming the C-X-X-C redox center and the C-terminal. The unique CAPC sequence of the C-X-X-C motif in the abTrx1 redox center was characterized by mutagenesis. This study contributes to the field of drug designing against superbugs. © 2022 Elsevier Inc. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | High-resolution crystal structure of Acinetobacter baumannii thioredoxin 1 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2022.03.134 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, v.608, pp 1 - 7 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000790443700001 | - |
dc.identifier.scopusid | 2-s2.0-85127333265 | - |
dc.citation.endPage | 7 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.volume | 608 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Acinetobacter baumannii | - |
dc.subject.keywordAuthor | Crystal structure | - |
dc.subject.keywordAuthor | Redox homeostasis | - |
dc.subject.keywordAuthor | Superbugs | - |
dc.subject.keywordAuthor | Thioredoxin | - |
dc.subject.keywordPlus | PROTEIN-STRUCTURE | - |
dc.subject.keywordPlus | CONSERVATION | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | TOOL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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