Sphingosine Analogue AAL-R Increases TLR7-Mediated Dendritic Cell Responses via p38 and Type I IFN Signaling Pathways
DC Field | Value | Language |
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dc.contributor.author | Seo, Young-Jin | - |
dc.contributor.author | Pritzl, Curtis J. | - |
dc.contributor.author | Vijayan, Madhuvanthi | - |
dc.contributor.author | Blake, Celeste R. | - |
dc.contributor.author | McClain, Mariah E. | - |
dc.contributor.author | Hahm, Bumsuk | - |
dc.date.accessioned | 2022-05-18T00:40:26Z | - |
dc.date.available | 2022-05-18T00:40:26Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.issn | 1550-6606 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57762 | - |
dc.description.abstract | Sphingosine analogues display immunosuppressive activities and thus have therapeutic potential in the treatment of autoimmune diseases. In this study, we investigated the effects of the sphingosine analogue AAL-R (FTY720 derivative) on dendritic cell (DC) response upon TLR stimulation. Unlike its known immunosuppressive activity, AAL-R increased TLR7-mediated DC responses by elevating the levels of MHC class I and costimulatory molecules and type I IFN expression and by enhancing the capacity of DCs to induce CD84(+) T cell proliferation. Importantly, the stimulatory activity of AAL-R was dependent on type I IFN signaling, as type I IFN receptor-deficient DCs failed to respond to AAL-R. Also, AAL-R activated p38 MAPK to increase type I IFN synthesis and TLR7-mediated DC maturation. These findings enhance our understanding of sphingosine regulation of the host immune system, in particular upon pathogenic infections. The Journal of Immunology, 2012, 188: 4759-4768. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | Sphingosine Analogue AAL-R Increases TLR7-Mediated Dendritic Cell Responses via p38 and Type I IFN Signaling Pathways | - |
dc.type | Article | - |
dc.identifier.doi | 10.4049/jimmunol.1102754 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.188, no.10, pp 4759 - 4768 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000303634300007 | - |
dc.identifier.scopusid | 2-s2.0-84861152862 | - |
dc.citation.endPage | 4768 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 4759 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 188 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTOR-7 | - |
dc.subject.keywordPlus | VIRAL-INFECTION | - |
dc.subject.keywordPlus | LYMPHOID ORGANS | - |
dc.subject.keywordPlus | INFLUENZA-VIRUS | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | STRANDED-RNA | - |
dc.subject.keywordPlus | FTY720 | - |
dc.subject.keywordPlus | SPHINGOSINE-1-PHOSPHATE | - |
dc.subject.keywordPlus | 1-PHOSPHATE | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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