Induction of hypoxia-inducible factor-1a inhibits drug-induced apoptosis in the human leukemic cell line HL-60
DC Field | Value | Language |
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dc.contributor.author | Yook, Yeon-Joo | - |
dc.contributor.author | Seo, Young-Jin | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Ko, Sang-Hyeok | - |
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Lee, Jeong Jin | - |
dc.contributor.author | Jeong, Gajin | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.date.accessioned | 2022-05-18T01:40:06Z | - |
dc.date.available | 2022-05-18T01:40:06Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 2287-979X | - |
dc.identifier.issn | 2288-0011 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57768 | - |
dc.description.abstract | Background Leukemic cells originate from hypoxic bone marrow, which protects them from anti-cancer drugs. Although many factors that cause drug resistance in leukemic cells have been studied, the effect of hypoxia on drug-induced apoptosis is still poorly understood. Methods In this study, we examined the effect of hypoxia on anti-leukemic drug resistance in leukemic cell lines treated with cobalt chloride (CoCl2), a hypoxia-mimetic agent. Cellular proliferation was evaluated using the methyl thiazolyl tetrazolium (MTT) assay. Flow cytometry analysis and western blots were performed to investigate apoptosis-related proteins. Results Unlike its previously known apoptotic effect, the expression of HIF-1a increased the survival rate of human promyelocytic leukemia HL-60 cells when these cells were exposed to anti-leukemic drugs; these effects were mediated by heat-shock protein HSP70 and the pro-apoptotic protein Bax. Conclusion These findings may provide new insights for understanding the mechanisms underlying hypoxia and for designing new therapeutic strategies for acute myeloid leukemia. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한혈액학회 | - |
dc.title | Induction of hypoxia-inducible factor-1a inhibits drug-induced apoptosis in the human leukemic cell line HL-60 | - |
dc.type | Article | - |
dc.identifier.doi | 10.5045/kjh.2010.45.3.158 | - |
dc.identifier.bibliographicCitation | Blood Research, v.45, no.3, pp 158 - 163 | - |
dc.identifier.kciid | ART001481942 | - |
dc.description.isOpenAccess | Y | - |
dc.citation.endPage | 163 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 158 | - |
dc.citation.title | Blood Research | - |
dc.citation.volume | 45 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Hypoxia | - |
dc.subject.keywordAuthor | Arsenic trioxide | - |
dc.subject.keywordAuthor | HIF-1a | - |
dc.subject.keywordAuthor | Cobalt chloride | - |
dc.subject.keywordAuthor | Bax | - |
dc.subject.keywordAuthor | HSP70 | - |
dc.description.journalRegisteredClass | kci | - |
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